Thanks to its safety and accessibility, magnetic resonance imaging (MRI) is extensively used
in clinical routine and research field, largely contributing to our understanding of the …

Hippocampal atrophy, as evidenced using magnetic resonance imaging (MRI), is one of the
most validated, easily accessible and widely used biomarkers of Alzheimer's disease (AD) …

The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's
disease (AD), on human brain cellular function remains unclear. Here, we investigated the …

Currently, over five million Americans suffer with Alzheimer's disease (AD). In the absence of
a cure, this number could increase to 13.8 million by 2050. A critical goal of biomedical …

The vast majority of Alzheimer's disease (AD) cases are late onset (LOAD), which is
genetically complex with heritability estimates up to 80%. Apolipoprotein E (APOE) has been …

Neurovascular dysfunction, including blood–brain barrier (BBB) breakdown and cerebral
blood flow (CBF) dysregulation and reduction, are increasingly recognized to contribute to …

Although the hippocampus is one of the most studied structures in the human brain, limited
quantitative data exist on its 3D organization, anatomical variability, and effects of disease …

The hippocampus is composed of distinct subfields: the four cornu ammonis areas (CA1‐
CA4), dentate gyrus (DG), and subiculum. The few in vivo studies of human hippocampal …

Abstract Introduction Apolipoprotein E (APOE)-ε4 is the major genetic risk factor for
Alzheimer's disease. However, the dose-dependent impact of this allele on brain …

Objective: Alcohol use disorder (AUD) is a complex, dynamic condition that waxes and
wanes with unhealthy drinking episodes and varies in drinking patterns and effects on brain …