Triazoles and their derivatives: Chemistry, synthesis, and therapeutic applications
Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior
pharmacological applications. Structurally, there are two types of five-membered triazoles: 1 …
pharmacological applications. Structurally, there are two types of five-membered triazoles: 1 …
Benzimidazole-triazole hybrids as antimicrobial and antiviral agents: A systematic review
M Marinescu - Antibiotics, 2023 - mdpi.com
Bacterial infections have attracted the attention of researchers in recent decades, especially
due to the special problems they have faced, such as their increasing diversity and …
due to the special problems they have faced, such as their increasing diversity and …
The 1, 2, 3-triazole 'all-in-one'ring system in drug discovery: A good bioisostere, a good pharmacophore, a good linker, and a versatile synthetic tool
ABSTRACT Introduction The 1, 2, 3-triazole ring occupies an important space in medicinal
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
Quinoline‐derivatives as privileged scaffolds for medicinal and pharmaceutical chemists: A comprehensive review
The quinoline scaffolds are privileged for their numerous biological activities in the
pharmaceutical field. This moiety constitutes a well‐known space in several marketed …
pharmaceutical field. This moiety constitutes a well‐known space in several marketed …
[HTML][HTML] Insight into non-nucleoside triazole-based systems as viral polymerases inhibitors
R Bivacqua, M Barreca, V Spanò, MV Raimondi… - European Journal of …, 2023 - Elsevier
Viruses have been recognized as the etiological agents responsible for many pathological
conditions ranging from asymptomatic infections to serious diseases, even leading to death …
conditions ranging from asymptomatic infections to serious diseases, even leading to death …
1, 2, 3-triazole-benzofused molecular conjugates as potential antiviral agents against SARS-CoV-2 virus variants
SARS-CoV-2 and its variants, especially the Omicron variant, remain a great threat to human
health. The need to discover potent compounds that may control the SARS-CoV-2 virus …
health. The need to discover potent compounds that may control the SARS-CoV-2 virus …
A novel coumarin-triazole-thiophene hybrid: synthesis, characterization, ADMET prediction, molecular docking and molecular dynamics studies with a series of SARS …
Synthesis, characterization and theoretical studies of a novel coumarin-triazole-thiophene
hybrid 4-(((4-ethyl-5-(thiophen-2-yl)-4 H-1, 2, 4-triazol-3-yl) thio) methyl)-6, 7-dimethyl-2 H …
hybrid 4-(((4-ethyl-5-(thiophen-2-yl)-4 H-1, 2, 4-triazol-3-yl) thio) methyl)-6, 7-dimethyl-2 H …
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal
Unprecedented efforts of the researchers have been witnessed in the recent past towards
the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit …
the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit …
Potential RNA-dependent RNA polymerase (RdRp) inhibitors as prospective drug candidates for SARS-CoV-2
MS Bekheit, SS Panda, AS Girgis - European Journal of Medicinal …, 2023 - Elsevier
The SARS-CoV-2 pandemic is considered as one of the most disastrous pandemics for
human health and the world economy. RNA-dependent RNA polymerase (RdRp) is one of …
human health and the world economy. RNA-dependent RNA polymerase (RdRp) is one of …
A review: Synthetic approaches and biological applications of triazole derivatives
The triazole scaffold is a key element in heterocyclic chemistry, giving a fundamental
building block in organic, medicinal chemistry, and material science chemistry. Triazole …
building block in organic, medicinal chemistry, and material science chemistry. Triazole …