Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with high
mortality and morbidity rate affecting both upper and lower motor neurons (MN). Muscle …

Batten disease (also known as neuronal ceroid lipofuscinoses) constitutes a family of
devastating lysosomal storage disorders that collectively represent the most common …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving
neuroinflammation and T cell infiltration in the central nervous system. However, the …

The complement system is a collection of soluble and membrane-bound proteins that
together act as a powerful amplifier of the innate and adaptive immune systems. Although its …

Abstract Background Low-dose interleukin-2 (ld-IL-2) enhances regulatory T-cell (Treg)
function in auto-inflammatory conditions. Neuroinflammation being a pathogenic feature of …

Alzheimer's disease is a multifactorial disease that exhibits cognitive deficits, neuronal loss,
amyloid plaques, neurofibrillary tangles and neuroinflammation in the brain. Hence, a multi …

Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative
disease. Despite decades of research and many new insights into disease biology over the …

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a
progressive neurodegenerative disease that affects both upper and lower motor neurons …

While a mutation in C9ORF72 is the most common genetic contributor to amyotrophic lateral
sclerosis (ALS), much remains to be learned concerning the function of the protein normally …

Abstract Introduction/Aims We tested safety, tolerability, and target engagement of
tocilizumab in amyotrophic lateral sclerosis (ALS) patients. Methods Twenty‐two …