Systematic review of safety of selective androgen receptor modulators in healthy adults: implications for recreational users

JD Vignali, KC Pak, HR Beverley, JP DeLuca… - Journal of …, 2023 - mdpi.com
Selective Androgen Receptor Modulators (SARMs) are not FDA approved, and obtaining
SARMs for personal use is illegal. Nevertheless, SARM use is increasingly popular amongst …

Androgen receptor and cardiovascular disease: a potential risk for the abuse of supplements containing selective androgen receptor modulators

E Hall, MF Vrolijk - Nutrients, 2023 - mdpi.com
The androgen receptor (AR) is a member of the family of ligand-activated transcription
factors. Selective androgen receptor modulators (SARMs) exert their biological function …

Social media's impact on widespread SARMs abuse

HA Hahamyan, N Vasireddi, JE Voos… - The Physician and …, 2023 - Taylor & Francis
Recreational and professional athletes are increasingly abusing Selective Androgen
Receptor Modulators (SARMs) as performance enhancing drugs (PEDs). Simultaneously …

[HTML][HTML] Sex-specific cytotoxicity of ostarine in cardiomyocytes

N Leciejewska, E Pruszyńska–Oszmałek… - Molecular and Cellular …, 2023 - Elsevier
Ostarine is the most popular compound in the selective androgen receptor modulator group
(SARMs). Ostarine is used as a physical performance-enhancing agent. The abuse of this …

Social media may cause emergent SARMs abuse by athletes: A content quality analysis of the most popular YouTube videos

N Vasireddi, HA Hahamyan, Y Kumar… - The Physician and …, 2023 - Taylor & Francis
ABSTRACT Objectives Selective Androgen Receptor Modulators (SARMs) social media
interest is at an all-time high. The aim of this study is to analyze the:(1) quality;(2) …

Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: analysis of suspected cases

N Leciejewska, K Jędrejko, VM Gómez-Renaud… - European Journal of …, 2024 - Springer
Purpose Selective androgen receptor modulators (SARMs) have demonstrated agonist
activity on the androgen receptor in various tissues, stimulating muscle mass growth and …

Human in vivo metabolism and elimination behavior of micro-dosed selective androgen receptor modulator RAD140 for doping control purposes

F Wagener, L Euler, C Görgens, S Guddat, M Thevis - Metabolites, 2022 - mdpi.com
RAD140 is a selective androgen receptor modulator which has been abused in sporting
competitions. Its use is prohibited by the World Anti-Doping Agency (WADA) for athletes at …

RAD140 (Testolone) negatively impacts skeletal muscle adaptation, frailty status and mortality risk in female mice

AM Brown, MS Ganjayi… - Clinical and Experimental …, 2023 - Wiley Online Library
RAD140 is a selective androgen receptor modulator that produces anabolic effects within
skeletal muscle. Thus, RAD140 may be effective at treating sarcopenia. No long‐term …

[HTML][HTML] Pre-treatment with galectin-1 attenuates lipopolysaccharide-induced myocarditis by regulating the Nrf2 pathway

L Shen, K Lu, Z Chen, Y Zhu, C Zhang… - European Journal of …, 2023 - ncbi.nlm.nih.gov
Abstract Galectin-1 (Gal-1), a member of a highly conserved family of animal lectins, plays a
crucial role in controlling inflammation and neovascularization. However, the potential role …

Ostarine blunts the effect of endurance training on submaximal endurance in rats

V Vasilev, N Boyadjiev, P Hrischev, F Gerginska… - Naunyn-Schmiedeberg's …, 2024 - Springer
The purpose of this study is to study the effects of ostarine alone and in combination with
endurance training in sexually mature, male Wistar rats. The rats were divided into a …