Simple Summary Pancreatic ductal adenocarcinoma is a leading cause of cancer death
worldwide. Due to the frequently late diagnosis, early metastasis and high therapy …

Notwithstanding recent treatment advances in metastatic colorectal cancer (mCRC),
chemotherapy with a combination of a fluoropyrimidine and a folate agent, often 5 …

While there have been rapid advances in developing new and more targeted drugs to treat
cancer, much less progress has been made in individualizing dosing. Even though the …

Fluorouracil (5-FU) and oral fluoropyrimidines, such as capecitabine, are widely used in the
treatment of cancer, especially gastrointestinal tumors and breast cancer, but their …

Fluoropyrimidines (FP; 5‐fluorouracil, capecitabine, and tegafur) are a commonly prescribed
class of antimetabolite chemotherapies, used for various solid organ malignancies in over 2 …

Background The optimal treatment for metastatic high-grade gastroenteropancreatic (GEP)
neuroendocrine neoplasms when Ki-67≤ 55% is unknown. A prospective multi-centre …

Background The main cause for fluoropyrimidine-related toxicity is deficiency of the
metabolizing enzyme dihydropyrimidine dehydrogenase (DPD). In 2020, the European …

Chemotherapy, as an important clinical treatment, has greatly enhanced survival in cancer
patients, but the side effects and long-term sequelae bother both patients and clinicians. 5 …

The implementation of pharmacogenetic testing into clinical practice has been a slow
process so far. Here, we review the implementation of pre-treatment testing of …

Background: Awareness about the importance of implementing DPYD pharmacogenetics in
clinical practice to prevent severe side effects related to the use of fluoropyrimidines has …