Covering: 1970 to 2020 By definition total synthesis is the art and science of making the
molecules of living Nature in the laboratory, and by extension, their analogues. Although …

The advent of organic synthesis in the 19th century, serendipitous as it was, set in motion a
revolution in science that continues to evolve into increasing levels of sophistication and to …

The enantioselective total synthesis of latanoprost, an antiglaucoma agent, has been
accomplished with excellent diastereo-and enantioselectivities in a pot-economical manner …

The architecturally symmetrical and synthetically challenging marine natural products
lomaiviticins A and B present alluring synthetic targets due to their molecular complexity …

Macrocyclic dimeric lactones have pharmacological activities that make them attractive
synthetic targets, but typical synthetic strategies employ an iterative approach to construct …

An enantioselective synthesis of 15-deoxy-Δ12, 14-prostaglandin J2 is reported. The
synthesis begins with the preparation of enantiopure 3-oxodicyclopentadiene by a lipase …

In the total stereo-controlled synthesis of natural prostaglandins (PGs) and their structural
analogs, a vast class of compounds and drugs, known as the lactones, are encountered in a …

The total synthesis of a docosahexaenoic-acid-derived prostaglandin, 4, 11-diepi-4-F4t-
neuroprostane, featuring a complex lateral chain was achieved for the first time. A novel …

The rapid assembly of complex organic molecules from simple and structurally diverse
building blocks is a prevalent challenge in organic synthesis. The Pauson‐Khand reaction …

Prostaglandins are a family of molecules that possess important biological properties, and
some of the analogues are used as medicines. Many synthetic methods have been …