Basic and applied uses of genome‐scale metabolic network reconstructions of Escherichia coli

D McCloskey, BØ Palsson, AM Feist - Molecular systems biology, 2013 - embopress.org
The genome‐scale model (GEM) of metabolism in the bacterium Escherichia coli K‐12 has
been in development for over a decade and is now in wide use. GEM‐enabled studies of E …

Computational approaches to design and test plant synthetic metabolic pathways

A Küken, Z Nikoloski - Plant Physiology, 2019 - academic.oup.com
Successfully designed and implemented plant-specific synthetic metabolic pathways hold
promise to increase crop yield and nutritional value. Advances in synthetic biology have …

Critical assessment of genome-scale metabolic networks: the need for a unified standard

A Ravikrishnan, K Raman - Briefings in bioinformatics, 2015 - academic.oup.com
Genome-scale metabolic networks have been reconstructed for several organisms. These
metabolic networks provide detailed information about the metabolism inside the cells …

Mathematical modeling of unicellular microalgae and cyanobacteria metabolism for biofuel production

C Baroukh, R Muñoz-Tamayo, O Bernard… - Current opinion in …, 2015 - Elsevier
Highlights•Mathematical modeling can help to better understand microalgae metabolism.•A
better understanding of metabolism can guide optimization of biofuels production.•The …

Photorespiratory Bypasses Lead to Increased Growth in Arabidopsis thaliana: Are Predictions Consistent with Experimental Evidence?

G Basler, A Küken, AR Fernie… - Frontiers in Bioengineering …, 2016 - frontiersin.org
Arguably, the biggest challenge of modern plant systems biology lies in predicting the
performance of plant species, and crops in particular, upon different intracellular and …

Computational prediction of essential metabolic genes using constraint-based approaches

G Basler - Gene Essentiality: Methods and Protocols, 2015 - Springer
In this chapter, we describe the application of constraint-based modeling to predict the
impact of gene deletions on a metabolic phenotype. The metabolic reactions taking place …

[PDF][PDF] Metabolic modeling under non-balanced growth. Application to microalgae for biofuels production

C Baroukh - 2014 - researchgate.net
Unicellular photoautotrophic microorganisms convert light photons into cell energy and fix
carbon dioxide (CO2). These eukaryotes (microalgae) or prokaryotes (cyanobacteria) …

Modeling Metabolic Networks and their Environment Interaction

MB Abarca - 2017 - theses.hal.science
Metabolic networks allows to the user the construction of detailed models using high
resolution 'omics datasets. In particular, Constrained Based Models (CBMs) are used to …

Les effets cardioprotecteurs de peptides dérivés des sécrétagogues de l'hormone de croissance dans le modèle d'ischémie-reperfusion du myocarde murin

DN Huynh - 2019 - papyrus.bib.umontreal.ca
Les peptides sécrétagogues de l'hormone de croissance (GHRP) sont des peptides
synthétiques qui stimulent la sécrétion de l'hormone de croissance (HC) après la liaison …

OPINION PAPER Evolutionary Constraint-Based Formulation Requires New Bi-level Solving Techniques

M Budinich, J Bourdon, A Larhlimi… - Computational Methods in …, 2015 - Springer
Abstract Constraint Based Methods had been successfully used to simulate genome-scale
metabolic behaviors over a range of experimental conditions. In most applications …