Melatonin is remarkably functionally diverse with actions as a free radical scavenger and
antioxidant, circadian rhythm regulator, anti‐inflammatory and immunoregulating molecule …

Abstract Melatonin (N‐acetyl‐5‐methoxytryptamine), an indoleamine produced in many
organs including the pineal gland, was initially characterized as a hormone primarily …

G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors
transmitting extracellular signals into cells. Here we show that central components of a …

Oxidative stress has been proven to be related to the onset of a large number of health
disorders. This chemical stress is triggered by an excess of free radicals, which are …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

Melatonin was discovered to be a direct free radical scavenger less than 10 years ago.
Besides its ability to directly neutralize a number of free radicals and reactive oxygen and …

Melatonin was recently reported to be an effective free radical scavenger and antioxidant.
Melatonin is believed to scavenge the highly toxic hydroxyl radical, the peroxynitrite anion …

Abstract Melatonin (N-acetyl-5-methoxytryptamine), an endogenously produced indole
found throughout the animal kingdom, was recently reported, using a variety of techniques …

Melatonin is a potent endogenous free radical scavenger, actions that are independent of its
many receptor-mediated effects. In the last several years, hundreds of publications have …

This review briefly summarizes the multiple actions by which melatonin reduces the
damaging effects of free radicals and reactive oxygen and nitrogen species. It is well …