Nuclear clearance and cytoplasmic mislocalization of the essential RNA binding protein,
TDP-43, is a pathologic hallmark of amyotrophic lateral sclerosis, frontotemporal dementia …

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease with an extremely
heterogeneous clinical and genetic phenotype. In our efforts to find therapies for ALS, the …

Amyotrophic lateral sclerosis (ALS) is a rare, devastating disease, causing movement
impairment, respiratory failure and ultimate death. A plethora of genetic, cellular and …

Over the years, researchers have leveraged a host of different in vivo models in order to
dissect amyotrophic lateral sclerosis (ALS), a neurodegenerative/neuroinflammatory …

Objective To identify potential diagnostic and prognostic biomarkers for clinical management
and clinical trials in amyotrophic lateral sclerosis. Methods We analysed proteomics data of …

Identifying genetic modifiers of familial amyotrophic lateral sclerosis (ALS) may reveal
targets for therapeutic modulation with potential application to sporadic ALS. GGGGCC …

Amyotrophic lateral sclerosis (ALS) is a devastating adult-onset neurodegenerative disease
characterized by the progressive degeneration of upper and lower motoneurons. Most ALS …

Inflammation is a central element of many neurodegenerative diseases. Formyl peptide
receptors (FPRs) can trigger several receptor-dependent signal transduction pathways that …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that leads to death
by progressive paralysis and respiratory failure within 2-4 years of onset. About 90-95% of …

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder
characterized by the loss of upper and lower motor neurons. In general, patients succumb to …