BACKGROUND The essential amino acid tryptophan is a substrate for the generation of
several bioactive compounds with important physiological roles. Only a small fraction of …

Aryl hydrocarbon receptor (AhR) is a member of the basic helix–loop–helix–(bHLH)
superfamily of transcription factors, which are associated with cellular responses to …

A number of bacteria, and some plants, produce large quantities of indole, which is
widespread in animal intestinal tracts and in the rhizosphere. Indole, as an interspecies and …

Background A vast diversity of microbes colonizes in the human gastrointestinal tract,
referred to intestinal microbiota. Microbiota and products thereof are indispensable for …

The signalling molecule indole occurs in significant amounts in the mammalian intestinal
tract and regulates diverse microbial processes, including bacterial motility, biofilm …

Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that induces the
expression of a broad range of downstream genes such as cytochromes P450 enzymes and …

Indole-3-acetic acid (IAA) belongs to the family of auxin indole derivatives. IAA regulates
almost all aspects of plant growth and development, and is one of the most important plant …

The intestine is the most densely colonized region of the body, inhabited by a diverse
community of microbes. The functional significance of the intestinal microbiota is not yet fully …

Caenorhabditis elegans, a non-parasitic nematode emerges as a relevant and powerful
candidate as an in vivo model for microorganisms-microorganisms and microorganisms …

The topic of uremic toxicity has received broad attention from the nephrological community
over the past few decades. An aspect that is much less often considered is the possibility …