Genotoxicity data are mainly interpreted in a qualitative way, which typically results in a
binary classification of chemical entities. For more than a decade, there has been a …

Hydroxyurea (hydroxycarbamide) is approved for treating both children and adults with
sickle cell anaemia (SCA). Fetal haemoglobin (HbF) induction is the primary treatment …

In 2008 we published recommendations on chemicals that would be appropriate to evaluate
the sensitivity and specificity of new/modified mammalian cell genotoxicity tests, in particular …

The in vivo Pig-a assay uses flow cytometry to measure phenotypic variants for antibody
binding to cell surface glycosylphosphatidylinositol (GPI)-anchored proteins. There is good …

The screen‐and‐bin approach for interpretation of genotoxicity data is predicated on three
false assumptions: that genotoxicants are rare, that genotoxicity dose–response functions do …

Several endpoints associated with cellular responses to DNA damage as well as overt
cytotoxicity were multiplexed into a miniaturized,“add and read” type flow cytometric assay …

We previously described a multiplexed in vitro genotoxicity assay based on flow cytometric
analysis of detergent‐liberated nuclei that are simultaneously stained with propidium iodide …

The working group reached complete or majority agreement on many issues. Results from
TGR and in vivo comet assays for 91 chemicals showed they have similar ability to detect in …

Three-dimensional (3D) culture systems are increasingly being used for genotoxicity studies
due to improved cell-to-cell interactions and tissue-like structures that are limited or lacking …

The in vitro MultiFlow® DNA Damage Assay multiplexes γH2AX, p53, phospho‐histone H3,
and polyploidization biomarkers into a single flow cytometric analysis. The current report …