This review is provided in recognition of the extensive contributions of Dr. Robert J.
Lefkowitz to the G protein-coupled receptor (GPCR) field and to celebrate his 75th birthday …

G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the
modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory …

Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a
versatile protein that acts as a signaling hub by modulating G protein-coupled receptor …

G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β …

Decompensated cirrhosis is characterized by exuberant systemic inflammation. Although the
inducers of this feature remain unknown, the presence of circulating forms of oxidized …

Elevated expression of the chemokine receptors CXCR4 and ACKR3 and of their cognate
ligand CXCL12 is detected in a wide range of tumors and the tumor microenvironment …

Increasing evidences point to G protein-coupled receptor kinases (GRKs), a subfamily of
protein kinase A/G/C-like kinases, as relevant players in cancer progression, in a cell-type …

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin
resistance and inflammation, and the pathogenic mechanism of NAFLD is poorly …

Introduction: G protein-coupled receptor (GPCR) kinase-2 (GRK2) is a regulator of GPCRs,
in particular β-adrenergic receptors (ARs), and as demonstrated by decades of investigation …

G protein-coupled receptor kinase type 2 (GRK2) and β-arrestin2 are representative proteins
that regulate the transduction and trafficking of G protein-coupled receptor (GPCR) …