Iron–sulfur clusters as inhibitors and catalysts of viral replication
K Honarmand Ebrahimi, S Ciofi-Baffoni… - Nature Chemistry, 2022 - nature.com
A virus hijacks host cellular machineries and metabolites in order to reproduce. In response,
the innate immune system activates different processes to fight back. Although many aspects …
the innate immune system activates different processes to fight back. Although many aspects …
[HTML][HTML] Structure–function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease
S Tamir, ML Paddock, M Darash-Yahana-Baram… - … et Biophysica Acta (BBA …, 2015 - Elsevier
A novel family of 2Fe–2S proteins, the NEET family, was discovered during the last decade
in numerous organisms, including archea, bacteria, algae, plant and human; suggesting an …
in numerous organisms, including archea, bacteria, algae, plant and human; suggesting an …
Redox-dependent gating of VDAC by mitoNEET
MitoNEET is an outer mitochondrial membrane protein essential for sensing and regulation
of iron and reactive oxygen species (ROS) homeostasis. It is a key player in multiple human …
of iron and reactive oxygen species (ROS) homeostasis. It is a key player in multiple human …
Alternative FeS cluster ligands: tuning redox potentials and chemistry
DW Bak, SJ Elliott - Current opinion in chemical biology, 2014 - Elsevier
Highlights•Properties and functions of biological Fe–S clusters with His-ligands are
examined.•Rieske clusters show increased redox potential and PCET due to His …
examined.•Rieske clusters show increased redox potential and PCET due to His …
Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor protein
JA Zuris, Y Harir, AR Conlan… - Proceedings of the …, 2011 - National Acad Sciences
MitoNEET (mNT) is an outer mitochondrial membrane target of the thiazolidinedione
diabetes drugs with a unique fold and a labile [2Fe-2S] cluster. The rare 1-His and 3-Cys …
diabetes drugs with a unique fold and a labile [2Fe-2S] cluster. The rare 1-His and 3-Cys …
The expanding utility of iron-sulfur clusters: Their functional roles in biology, synthetic small molecules, maquettes and artificial proteins, biomimetic materials, and …
AE Boncella, ET Sabo, RM Santore, J Carter… - Coordination Chemistry …, 2022 - Elsevier
The ubiquity, structural variation, and functional diversity of iron-sulfur (Fe-S) clusters in
biological environments has long fascinated scientists. In nature, Fe-S clusters form a variety …
biological environments has long fascinated scientists. In nature, Fe-S clusters form a variety …
Characterization of the [2Fe-2S] Cluster of Escherichia coli Transcription Factor IscR
IscR is an Fe–S cluster-containing transcription factor involved in a homeostatic mechanism
that controls Fe–S cluster biogenesis in Escherichia coli. Although IscR has been proposed …
that controls Fe–S cluster biogenesis in Escherichia coli. Although IscR has been proposed …
Redox control of the human iron-sulfur repair protein MitoNEET activity via its iron-sulfur cluster
MP Golinelli-Cohen, E Lescop, C Mons… - Journal of Biological …, 2016 - ASBMB
Human mitoNEET (mNT) is the first identified Fe-S protein of the mammalian outer
mitochondrial membrane. Recently, mNT has been implicated in cytosolic Fe-S repair of a …
mitochondrial membrane. Recently, mNT has been implicated in cytosolic Fe-S repair of a …
Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast
The BolA homologue Fra2 and the cytosolic monothiol glutaredoxins Grx3 and Grx4
together play a key role in regulating iron homeostasis in Saccharomyces cerevisiae …
together play a key role in regulating iron homeostasis in Saccharomyces cerevisiae …
The unique fold and lability of the [2Fe-2S] clusters of NEET proteins mediate their key functions in health and disease
NEET proteins comprise a new class of [2Fe-2S] cluster proteins. In human, three genes
encode for NEET proteins: cisd1 encodes mitoNEET (mNT), cisd2 encodes the Nutrient …
encode for NEET proteins: cisd1 encodes mitoNEET (mNT), cisd2 encodes the Nutrient …