Malignant cells utilize diverse strategies that enable them to thrive under adverse conditions
while simultaneously inhibiting the development of anti-tumor immune responses. Hostile …

MicroRNAs (miRNA) are short, noncoding RNAs whose dysregulation has been implicated
in most, if not all, cancers. They regulate gene expression by suppressing mRNA translation …

Recent clinical trials have demonstrated the ability to durably control cancer in some
patients by manipulating T lymphocytes. These immunotherapies are revolutionizing cancer …

Dendritic cells (DCs) are required to initiate and sustain T cell-dependent anti-cancer
immunity. However, tumors often evade immune control by crippling normal DC function …

Simple Summary Cancer is a complex disease associated with deregulation of numerous
genes. In addition, redundant cellular pathways limit efficiency of monotarget drugs in …

Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to
affect disease progression in many human malignancies. Infiltration by mature, active DCs …

Highlights•MicroRNAs play a major role in cancer.•Several clinical trials with microRNA are
reported for cancer treatment.•Delivery of microRNA encounters several challenges.•We …

Cancer immunotherapy has revolutionized oncology practice. However, current protein and
cell therapy tools used in cancer immunotherapy are far from perfect, and there is room for …

With the advent of combined immunotherapies, personalized dendritic cell (DC)-based
vaccination could integrate the current standard of care for the treatment of a large variety of …

It has been almost two decades since the first link between microRNAs and cancer was
established. In the ensuing years, this abundant class of short noncoding regulatory RNAs …