HIV “shock and kill” therapy: In need of revision
The implementation of antiretroviral therapy 23 years ago has rendered HIV infection
clinically manageable. However, the disease remains incurable, since it establishes latent …
clinically manageable. However, the disease remains incurable, since it establishes latent …
Recent advances in design of fluorescence-based assays for high-throughput screening
Significant improvements in disease management have been achieved in the past few
decades. Using cancer as an example, survival rates have increased dramatically in …
decades. Using cancer as an example, survival rates have increased dramatically in …
Strategies to eradicate HIV from infected patients: elimination of latent provirus reservoirs
I Sadowski, FB Hashemi - Cellular and Molecular Life Sciences, 2019 - Springer
Abstract 35 years since identification of HIV as the causative agent of AIDS, and 35 million
deaths associated with this disease, significant effort is now directed towards the …
deaths associated with this disease, significant effort is now directed towards the …
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors
Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent
members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or …
members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or …
[HTML][HTML] Investigation of the medicinal significance of phytic acid as an indispensable anti-nutrient in diseases
I Abdulwaliyu, SO Arekemase, JA Adudu… - Clinical Nutrition …, 2019 - Elsevier
Background & aims Inadequate knowledge and intake of a balance diet is a contributing
factor of micronutrient deficiencies in developing countries. Phytic acid contributes in …
factor of micronutrient deficiencies in developing countries. Phytic acid contributes in …
Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir
An innovative approach to eliminate HIV-1-infected cells emerging out of latency, the major
hurdle to HIV-1 cure, is to pharmacologically reactivate viral expression and concomitantly …
hurdle to HIV-1 cure, is to pharmacologically reactivate viral expression and concomitantly …
Design, synthesis, and biological evaluation of novel 1, 3, 4-thiadiazole derivatives as potential antitumor agents against chronic myelogenous leukemia: Striking …
In an attempt to develop potent antitumor agents, new 1, 3, 4-thiadiazole derivatives were
synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines …
synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines …
African nightshades (Solanum nigrum complex): The potential contribution to human nutrition and livelihoods in sub‐Saharan Africa
Achieving zero hunger in sub‐Saharan Africa (SSA) without minimizing postharvest losses
of agricultural products is impossible. Therefore, a holistic approach is vital to end hunger …
of agricultural products is impossible. Therefore, a holistic approach is vital to end hunger …
In vitro and in silico evaluation of anticancer activity of new indole-based 1, 3, 4-oxadiazoles as EGFR and COX-2 inhibitors
Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) are crucial
targetable enzymes in cancer management. Therefore, herein, new 2-[(5-((1 H-indol-3-yl) …
targetable enzymes in cancer management. Therefore, herein, new 2-[(5-((1 H-indol-3-yl) …
EGFR-targeted pentacyclic triterpene analogues for glioma therapy
Glioma, particularly its most malignant form, glioblastoma multiforme (GBM), is the most
common and aggressive malignant central nervous system tumor. The drawbacks of the …
common and aggressive malignant central nervous system tumor. The drawbacks of the …