Enhancers are genomic DNA elements controlling spatiotemporal gene expression. Their
flexible organization and functional redundancies make deciphering their sequence-function …

Highlights•Genome-wide and single gene studies have revealed a variety of mechanisms by
which new expression patterns arise.•Studying newly evolved morphologies at the level of …

Abstract Schizophrenia's (SZ's) heritability and familial transmission have been known for
several decades; however, despite the clear evidence for a genetic component, it has been …

Deciphering the genetic bases that drive animal diversity is one of the major challenges of
modern biology. Although four decades ago it was proposed that animal evolution was …

Convergent phenotypic evolution is often caused by recurrent changes at particular nodes in
the underlying gene regulatory networks (GRNs). The genes at such evolutionary 'hotspots' …

Enhancers regulate precise spatial and temporal patterns of gene expression in eukaryotes
and, moreover, evolutionary changes in these modular cis-regulatory elements may …

Background Transcriptional regulation is a fundamental mechanism underlying biological
functions. In recent years, a broad array of RNA-Seq tools have been used to measure …

ABSTRACT DNA mutations that create new gene expression are important raw materials for
Darwinian evolution. One potential source of new gene regulation is mobile DNA, which can …

The evolutionary origins of morphological structures are thought to often depend upon the
redeployment of old genes into new developmental settings. Although many examples of cis …

Enriched region (ER) identification is a fundamental step in several next-generation
sequencing (NGS) experiment types. Yet, although NGS experimental protocols recommend …