Oxidative stress and chronic inflammation are known to be associated with the development
of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative …

Reactive oxidative species (ROS) toxicity remains an undisputed cause and link between
Alzheimer's disease (AD) and Type-2 Diabetes Mellitus (T2DM). Patients with both AD and …

This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …

The last 20–25 years have seen an explosion of interest in the role of NADPH oxidase
(NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium …

Mitochondrial reactive oxygen species (mROS) are routinely produced at several sites within
the organelle. The balance in their formation and elimination is maintained by a complex …

Vasodilation in response to low oxygen (O2) tension (hypoxic vasodilation) is an essential
homeostatic response of systemic arteries that facilitates O2 supply to tissues according to …

Extracellular vesicles (EVs), including microvesicles and exosomes, are emerging as
important regulators of homeostasis and pathophysiology. During pro-inflammatory and pro …

Heart failure (HF) is associated with elevated sympathetic tone and mechanical load. Both
systems activate signaling transduction pathways that increase cardiac output, but …

Resistance arteries and arterioles evolved as specialized blood vessels serving two
important functions:(a) regulating peripheral vascular resistance and blood pressure and (b) …

Chronic kidney disease (CKD) is a world health problem increasing dramatically. The onset
of CKD is driven by several mechanisms; among them, metabolic reprogramming and …