Throughout our lifespan, new sensory experiences and learning continually shape our
neuronal circuits to form new memories. Plasticity at the level of synapses has been …

Myelinated nerve fibers have evolved to enable fast and efficient transduction of electrical
signals in the nervous system. To act as an electric insulator, the myelin sheath is formed as …

Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …

Human brain development is underpinned by cellular and molecular reconfigurations
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …

Quantum biological tunnelling for electron transfer is involved in controlling essential
functions for life such as cellular respiration and homoeostasis. Understanding and …

Cerebral organoids provide an accessible system for investigations of cellular composition,
interactions, and organization but have lacked oligodendrocytes, the myelinating glia of the …

Myelin-forming oligodendrocytes (OLs) are formed continuously in the healthy adult brain. In
this work, we study the function of these late-forming cells and the myelin they produce …

Myelin is a multilayer lipid membrane structure that wraps and insulates axons, allowing for
the efficient propagation of action potentials. During developmental myelination of the …

Infants born prematurely are at high risk to develop white matter injury (WMI), due to
exposure to hypoxic and/or inflammatory insults. Such perinatal insults negatively impact the …

Central nervous system (CNS) myelination by oligodendrocytes (OLs) is a highly
orchestrated process involving well-defined steps from specification of neural stem cells into …