Cellular senescence is a homeostatic biological process characterized by a permanent state
of cell cycle arrest that can contribute to the decline of the regenerative potential and …

Genome instability has long been implicated as the main causal factor in aging. Somatic
cells are continuously exposed to various sources of DNA damage, from reactive oxygen …

The Sir2 histone deacetylase functions as a chromatin silencer to regulate recombination,
genomic stability, and aging in budding yeast. Seven mammalian Sir2 homologs have been …

Genetic and pharmacological intervention studies have identified evolutionarily conserved
and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing …

Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …

Ageing is driven by the inexorable and stochastic accumulation of damage in biomolecules
vital for proper cellular function. Although this process is fundamentally haphazard and …

DNA is a precious molecule. It encodes vital information about cellular content and function.
There are only two copies of each chromosome in the cell, and once the sequence is lost no …

Given the central role of DNA in life, and how ageing can be seen as the gradual and
irreversible breakdown of living systems, the idea that damage to the DNA is the crucial …

The autofluorescent pigments that accumulate in retinal pigment epithelial cells with aging
and in some retinal disorders have been implicated in the etiology of macular degeneration …

Accumulation of somatic mutations is thought to contribute to the aging process. Genomic
instability has been shown to increase during aging, suggesting an aberrant function of DNA …