Cyclic dinucleotides (CDNs) are highly versatile signalling molecules that control various
important biological processes in bacteria. The best-studied example is cyclic di-GMP (c-di …

Biofilms are a widely observed growth mode in which microbial communities are spatially
structured and embedded in a polymeric extracellular matrix. Here, we focus on the model …

Biofilm formation and biofilm-induced biodeterioration of surfaces have deeply affected the
life of our community. Cyclic dimeric guanosine monophosphate (c-di-GMP) is a small …

The intracellular signaling molecule cyclic di-GMP (c-di-GMP) regulates the lifestyle of
bacteria and controls many key functions and mechanisms. In the case of bacterial …

Bacteria and archaea rely on appendages called type IV pili (T4P) to participate in diverse
behaviors including surface sensing, biofilm formation, virulence, protein secretion and …

Highlights•A plethora of c-di-GMP metabolizing enzymes impact cellular processes in Vibrio
cholerae.•C-di-GMP receptors are diverse and target processes are controlled by different …

Biofilm formation by Vibrio cholerae facilitates environmental persistence, and
hyperinfectivity within the host. Biofilm formation is regulated by 3', 5'-cyclic diguanylate (c-di …

Cyclic diadenylate (c-di-AMP) is a widespread second messenger in bacteria and archaea
that is involved in the maintenance of osmotic pressure, response to DNA damage, and …

Biofilms are complex microbial architectures that encase microbial cells in a matrix
comprising self-produced extracellular polymeric substances. Microorganisms living in …

Since the discovery of c-di-GMP almost three decades ago, cyclic dinucleotides (CDNs)
have emerged as widely used signaling molecules in most kingdoms of life. The family of …