The story of rapamycin is a pharmaceutical fairytale. Discovered as an antifungal activity in a
soil sample collected on Easter Island, this macrocyclic lactone and its derivatives are now …

The green lineage of chlorophyte algae and streptophytes form a large and diverse clade
with multiple independent transitions to produce multicellular and/or macroscopically …

Abstract TARGET OF RAPAMYCIN (TOR) kinase controls many cellular functions in
eukaryotic cells in response to stress and nutrient availability and was shown to be essential …

Background Flowering plant development is wholly reliant on growth from meristems, which
contain totipotent cells that give rise to all post-embryonic organs in the plant. Plants are …

Translational control mechanisms are, besides transcriptional control and mRNA stability,
the most determining for final protein levels. A large number of accessory factors that assist …

Although the eukaryotic TOR (target of rapamycin) kinase signalling pathway has emerged
as a key player for integrating nutrient-, energy-and stress-related cues with growth and …

Plant cells contain specialized structures, such as a cell wall and a large vacuole, which play
a major role in cell growth. Roots follow an organized pattern of development, making them …

One of the most important demands of multicellularity is the co-ordination of cell proliferation
and cell growth to allow the ultimate differentiation of functional organs and tissues. In …

Target of rapamycin (TOR) is a conserved eukaryotic serine/threonine kinase that functions
as a central controller of cell growth. TOR protein is structurally defined by the presence …

TOR (Target of rapamycin) kinase is a central component of a signal transduction pathway
that regulates cellular growth in response to nutrients, mitogens and growth factors in …