In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

Polymorphonuclear neutrophils (PMNs) figure prominently in host defense against infection
and in noninfectious inflammation. Mobilized early in an inflammatory response, PMNs …

The mycobacterium genus contains a broad range of species, including the human
pathogens M. tuberculosis and M. leprae. These bacteria are best known for their residence …

Optimal microbicidal activity of human polymorphonuclear leukocytes (PMN) relies on the
generation of toxic agents such as hypochlorous acid (HOCl) in phagosomes. HOCl …

The extensive use of antibiotics over the last decades is responsible for the emergence of
multidrug-resistant (MDR) microorganisms that are challenging health care systems …

Streptococcus pneumoniae is a serious human respiratory pathogen. It generates hydrogen
peroxide (H2O2) as part of its normal metabolism, yet it lacks enzymes that remove this …

Phagocytes, such as neutrophils and macrophages, engulf microbes into phagosomes and
launch chemical attacks to kill and degrade them. Such a critical innate immune function …

Huwa-San peroxide (hydrogen peroxide; HSP) is a NSF Standard 60 (maximum 8mg/L-1)
new generation peroxide stabilized with ionic silver suitable for continuous disinfection of …

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that causes serious
infections in humans, notably cystic fibrosis. P. aeruginosa faces various stresses such as …

Neutrophils are often the major leukocyte at sites of mycobacterial infection, yet little is
known about their ability to kill mycobacteria. In this study we have investigated whether the …