The regulation of gene expression is fundamental for life. Whereas the role of transcriptional
regulation of gene expression has been studied for several decades, it has been clear over …

Proteomics is the field of study that includes the analysis of proteins, from either a basic
science prospective or a clinical one. Proteins can be investigated for their abundance …

Data-independent acquisition modes isolate and concurrently fragment populations of
different precursors by cycling through segments of a predefined precursor m/z range …

Single‐cell technologies are revolutionizing biology but are today mainly limited to imaging
and deep sequencing. However, proteins are the main drivers of cellular function and in …

The emergence and global spread of SARS-CoV-2 has resulted in the urgent need for an in-
depth understanding of molecular functions of viral proteins and their interactions with the …

Single-cell proteomics can reveal cellular phenotypic heterogeneity and cell-specific
functional networks underlying biological processes. Here, we present a streamlined …

Ribosome profiling has revealed pervasive but largely uncharacterized translation outside of
canonical coding sequences (CDSs). In this work, we exploit a systematic CRISPR-based …

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated
fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid …

A critical step in proteomics analysis is the optimal extraction and processing of protein
material to ensure the highest sensitivity in downstream detection. Achieving this requires a …

One of the first biological machineries to be created seems to have been the ribosome.
Since then, organisms have dedicated great efforts to optimize this apparatus. The …