Maintaining the structure of protein and peptide drugs has become one of the most important
goals of scientists in recent decades. Cold and thermal denaturation conditions …

SARS-CoV-2 is a novel β-coronavirus that caused the COVID-19 pandemic disease, which
spread rapidly, infecting more than 134 million people, and killing almost 2.9 million thus far …

Pharmaceuticals represent a significant contributor to the environmental impact of
healthcare. Biopharmaceuticals are a rapidly growing category in that industry. They provide …

Representative cultivation models are needed for designing efficient monoclonal antibody
(mAb) production processes. Simple Monod-type kinetic models could fail to capture …

While machine learning (ML) has made significant contributions to the biopharmaceutical
field, its applications are still in the early stages in terms of providing direct support for quality …

Monoclonal antibodies are leading the growing biopharmaceutical markets. To sustain the
increasing demand, manufacturing processes should be optimized to increase efficiency …

The production of therapeutic proteins in mammalian cell culture is an essential unit
operation in biopharmaceutical manufacture that can benefit from the predictive insights of …

Highlights•Temporal evolution of N-glycosylation is of rising interest.•Rapid detection with
predictive modeling could enable dynamic control of N-glycosylation.•Combinations of …

Glycosylation of recombinant therapeutics like monoclonal antibodies (mAbs) is a critical
quality attribute. N-glycans in mAbs are known to affect various effector functions, and …

Hydrolysates are used as media supplements although their role is not well characterized. In
this study, cottonseed hydrolysates, which contained peptides and galactose as …