Patient-derived xenograft models in cancer therapy: technologies and applications
Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted
into immunocompromised or humanized mice, have shown superiority in recapitulating the …
into immunocompromised or humanized mice, have shown superiority in recapitulating the …
[HTML][HTML] Orthotopic and metastatic tumour models in preclinical cancer research
SM Stribbling, C Beach, AJ Ryan - Pharmacology & Therapeutics, 2024 - Elsevier
Mouse models of disease play a pivotal role at all stages of cancer drug development. Cell-
line derived subcutaneous tumour models are predominant in early drug discovery, but …
line derived subcutaneous tumour models are predominant in early drug discovery, but …
Single-cell atlas of penile cancer reveals TP53 mutations as a driver of an aggressive phenotype, irrespective of human papillomavirus status, and provides clues for …
L Elst, G Philips, K Vandermaesen, A Bassez, F Lodi… - European Urology, 2024 - Elsevier
Background and objective TP53 loss-of-function (TP53LOF) mutations might be a driver of
poor prognosis and chemoresistance in both human papillomavirus (HPV)-independent …
poor prognosis and chemoresistance in both human papillomavirus (HPV)-independent …
Interplay Between Immune and Cancer-Associated Fibroblasts: A Path to Target Metalloproteinases in Penile Cancer
Extracellular matrix (ECM) remodeling and inflammation have been reported in penile
carcinomas (PeCa). However, the cell types and cellular crosstalk involved in PeCa are …
carcinomas (PeCa). However, the cell types and cellular crosstalk involved in PeCa are …
Transcriptomic, Proteomic, and Genomic Mutational Fraction Differences Based on HPV Status Observed in Patient-Derived Xenograft Models of Penile Squamous …
NM Zacharias, L Segarra, K Akagi, NW Fowlkes… - Cancers, 2024 - mdpi.com
Simple Summary Penile cancer is a rare but aggressive cancer. After it metastasizes, the
median survival time is less than 12 months. The overall response rate to common first-line …
median survival time is less than 12 months. The overall response rate to common first-line …
Bioprinted research models of urological malignancy
Urological malignancy (UM) is among the leading threats to health care worldwide. Recent
years have seen much investment in fundamental UM research, including mechanistic …
years have seen much investment in fundamental UM research, including mechanistic …