The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

The conversion of acetylcholine binding into ion conduction across the membrane is
becoming more clearly understood in terms of the structure of the receptor and its transitions …

Type-A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of rapid
inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers …

Volatile anaesthetics have historically been considered to act in a nonspecific manner on
the central nervous system,. More recent studies, however, have revealed that the receptors …

Ion channels are membrane proteins that act as gated pathways for the movement of ions
across cell membranes. They play essential roles in the physiology of all cells. In recent …

Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …

The amino acid γ-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotrans-
mitter that mediates most of its effects through fast GABA-gated Cl−-channels (GABA AR) …

GABA A receptors are ligand-gated ion channels composed of five subunits that can be
opened by GABA and be modulated by multiple pharmacologically and clinically important …

Neurotransmitter receptor systems have been the focus of intensive pharmacological
research for more than 20 years for basic and applied scientific reasons, but only recently …

It is over forty years since the major neurotransmitters and their protein receptors were
identified, and over twenty years since determination of the first amino-acid sequences of the …