Prostaglandins and other eicosanoids in insects: biosynthesis and biological actions

D Stanley, Y Kim - Frontiers in Physiology, 2019 - frontiersin.org
This essay reviews the discoveries, synthesis, and biological significance of prostaglandins
(PGs) and other eicosanoids in insect biology. It presents the most current–and growing …

Salicylic acid, a plant hormone, suppresses phytophagous insect immune response by interrupting HMG-Like DSP1

MMI Mollah, HW Choi, I Yeam, JM Lee… - Frontiers in Physiology, 2021 - frontiersin.org
Salicylic acid is a plant hormone that can mediate various plant physiological processes.
Salicylic acid can bind to human high mobility group box 1 (HMGB1) and interrupt its role in …

HMGB1-like dorsal switch protein 1 triggers a damage signal in mosquito gut to activate dual oxidase via eicosanoids

S Ahmed, SM Sajjadian, Y Kim - Journal of Innate Immunity, 2022 - karger.com
Several mosquitoes transmit human pathogens by blood feeding, with the gut being the
main entrance for the pathogens. Thus, the gut epithelium defends the pathogens by …

Variation in pathogenicity of different strains of Xenorhabdus nematophila; Differential immunosuppressive activities and secondary metabolite production

MA Hasan, S Ahmed, MMI Mollah, D Lee… - Journal of invertebrate …, 2019 - Elsevier
Xenorhabdus nematophila, an entomopathogenic bacterium, is mutualistic with the
nematode Steinernema carpocapsae. The bacterium produces secondary metabolites to …

Dorsal switch protein 1 as a damage signal in insect gut immunity to activate dual oxidase via an eicosanoid, PGE2

MC Roy, S Ahmed, Y Kim - Frontiers in immunology, 2022 - frontiersin.org
Various microbiota including beneficial symbionts reside in the insect gut. Infections of
pathogens cause dysregulation of the microflora and threaten insect survival. Reactive …

Immune mediation of HMG-like DSP1 via Toll-Spätzle pathway and its specific inhibition by salicylic acid analogs

MMI Mollah, S Ahmed, Y Kim - PLoS Pathogens, 2021 - journals.plos.org
Xenorhabdus hominickii, an entomopathogenic bacterium, inhibits eicosanoid biosynthesis
of target insects to suppress their immune responses by inhibiting phospholipase A2 (PLA2) …

Biosynthetic pathway of arachidonic acid in Spodoptera exigua in response to bacterial challenge

MA Hasan, S Ahmed, Y Kim - Insect biochemistry and molecular biology, 2019 - Elsevier
Eicosanoids play crucial roles in mediating insect immune responses. In vertebrates,
phospholipase A 2 (PLA 2) releases arachidonic acid (AA) from phospholipids (PLs) for …

Virulent secondary metabolites of entomopathogenic bacteria genera, Xenorhabdus and Photorhabdus, inhibit phospholipase A2 to suppress host insect immunity

MMI Mollah, Y Kim - BMC microbiology, 2020 - Springer
Abstract Background Xenorhabdus and Photorhabdus are entomopathogenic bacteria that
cause septicemia and toxemia in insects. They produce secondary metabolites to induce …

Deletion mutant of PGE2 receptor using CRISPR-Cas9 exhibits larval immunosuppression and adult infertility in a lepidopteran insect, Spodoptera exigua

Y Kim, S Ahmed, MA Al Baki, S Kumar, K Kim… - Developmental & …, 2020 - Elsevier
Prostaglandins (PGs) mediate various physiological processes in insects and other
invertebrates, but there is very little information on PG receptors. This study identified a PGE …

PGE2 mediates hemocyte-spreading behavior by activating aquaporin via cAMP and rearranging actin cytoskeleton via Ca2+

S Ahmed, Y Kim - Developmental & Comparative Immunology, 2021 - Elsevier
Spreading behavior of hemocytes (= insect blood cells) is essential for cellular immune
responses against various microbial pathogens. It is activated by prostaglandin E 2 (PGE 2) …