The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

Intercellular signaling molecules, known as morphogens, act at a long range in developing
tissues to provide spatial information and control properties such as cell fate and tissue …

Fluorescence correlation spectroscopy (FCS) is a single molecule sensitive tool for the
quantitative measurement of biomolecular dynamics and interactions. Improvements in …

Cancer-associated fibroblasts (CAFs) are a crucial component in the tumor
microenvironment influencing cancer progression. Besides shaping the extracellular matrix …

The hindered diffusion model postulates that the movement of a signaling molecule through
an embryo is affected by tissue geometry and binding-mediated hindrance, but these effects …

Tunnelling nanotubes (TNTs) connect distant cells and mediate cargo transfer for
intercellular communication in physiological and pathological contexts. How cells generate …

Tissue-wide coordination of polarized cytoskeletal organization and cell behaviour, critical
for normal development, is controlled by asymmetric membrane localization of non …

Chemical signalling is the primary means by which cells communicate in the embryo. The
underlying principle refers to a group of ligand-producing cells and a group of cells that …

Wnt signalling is an essential pathway in embryogenesis, differentiation, cell motility,
development, and adult tissue homeostasis in vertebrates. The Wnt signalling network can …

Extracellular vesicles (EVs) are crucial for transferring bioactive materials between cells and
play vital roles in both health and diseases. Cellular protrusions, including filopodia and …