Precision medicine holds great promise to harness genetic and epigenetic cues for targeted
treatment of a variety of diseases, ranging from many types of cancers, neurodegenerative …

In analogy to split-protein systems, which rely on the appropriate fragmentation of protein
domains, split aptamers made of two or more short nucleic acid strands have emerged as …

Aptamers are single-stranded nucleic acid molecules that possess properties comparable to
those of protein monoclonal antibodies, and thus are clear alternatives to long established …

Background Aptamer has been called “chemical antibody” which displays the specific affinity
to target molecules compared to that of antibodies and possesses several therapeutic …

Aptamers are single-stranded DNA or RNA oligomers, identified from a random sequence
pool, with the ability to form unique and versatile tertiary structures that bind to cognate …

von Willebrand factor (VWF) plays a pivotal role in platelet adhesion and aggregation at
sites of high shear rates (eg, in coronary arteries that have stenotic or ruptured …

Western medicine often aims to specifically treat diseased tissues or organs. However, the
majority of current therapeutics failed to do so owing to their limited selectivity and the …

Covalent aptamers are novel biochemical tools for fast and selective transfer of labels to
target proteins. Equipped with cleavable electrophiles, these nucleic acid probes enable the …

Since the advent of practical methods for achieving DNA metallization, the use of nucleic
acids as templates for the synthesis of inorganic nanoparticles (NPs) has become an active …

Aptamers have a promising role in the field of life science and have been extensively
researched for application as analytical tools, therapeutic agents and as vehicles for …