Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …

The devastating effects and incurable nature of hereditary and sporadic retinal diseases
such as Stargardt disease, age-related macular degeneration or retinitis pigmentosa …

Signaling receptors dynamically exit cilia upon activation of signaling pathways such as
Hedgehog. Here, we find that when activated G protein-coupled receptors (GPCRs) fail to …

A diffusion barrier at the transition zone enables the compartmentalization of signaling
molecules by cilia. The BBSome and the small guanosine triphosphatase Arl6, which …

Cilia are surface-exposed organelles that dynamically concentrate signaling molecules to
organize sensory, developmental and homeostatic pathways. Entry and exit of signaling …

Bardet–Biedl syndrome (BBS) is a rare inherited disease caused by defects in the BBSome,
an octameric complex of BBS proteins. The BBSome is conserved in most organisms with …

Eukaryotic cells face the challenging task of transporting a variety of particles through the
complex intracellular milieu in order to deliver, distribute, and mix the many components that …

To serve vision, vertebrate rod and cone photoreceptors must detect photons, convert the
light stimuli into cellular signals, and then convey the encoded information to downstream …

Bardet–Biedl syndrome (BBS) is a ciliopathy resulting from defects in the BBSome, a
conserved protein complex. BBSome mutations affect ciliary membrane composition …