Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

The KCNQ1 voltage-gated potassium channel and its auxiliary subunit KCNE1 play a crucial
role in the regulation of the heartbeat. The stoichiometry of KCNQ1 and KCNE1 complex has …

Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …

Voltage-gated ion channels are crucial for both neuronal and cardiac excitability. Decades
of research have begun to unravel the intriguing machinery behind voltage sensitivity …

Polyunsaturated fatty acids (PUFAs) affect cardiac excitability. Kv7. 1 and the β-subunit
KCNE1 form the cardiac IKs channel that is central for cardiac repolarization. In this study …

Voltage-gated ion channels generate electrical currents that control muscle contraction,
encode neuronal information, and trigger hormonal release. Tissue-specific expression of …

Gating of voltage-dependent cation channels involves three general molecular processes:
voltage sensor activation, sensor-pore coupling, and pore opening. KCNQ1 is a voltage …

The KCNQ1 channel (also called Kv7. 1 or KvLQT1) belongs to the superfamily of voltage‐
gated K+ (Kv) channels. KCNQ1 shares several general features with other Kv channels but …

The cardiac-delayed rectifier K+ current (IKS) is carried by a complex of KCNQ1 (Q1)
subunits, containing the voltage-sensor domains and the pore, and auxiliary KCNE1 (E1) …