Understanding, predicting and achieving liver transplant tolerance: from bench to bedside

AW Thomson, J Vionnet… - Nature Reviews …, 2020 - nature.com
In the past 40 years, liver transplantation has evolved from a high-risk procedure to one that
offers high success rates for reversal of liver dysfunction and excellent patient and graft …

[PDF][PDF] Liver biopsy interpretation for causes of late liver allograft dysfunction

Banff Working Group, AJ Demetris - Hepatology, 2006 - Wiley Online Library
Abstract Evaluation of needle biopsies and extensive clinicopathological correlation play an
important role in the determination of liver allograft dysfunction occurring more than 1 year …

[HTML][HTML] 2016 comprehensive update of the Banff working group on liver allograft pathology: introduction of antibody-mediated rejection

AJ Demetris, C Bellamy, SG Hübscher, J O'leary… - American Journal of …, 2016 - Elsevier
The Banff Working Group on Liver Allograft Pathology reviewed and discussed literature
evidence regarding antibody-mediated liver allograft rejection at the 11th (Paris, France …

Activation of YAP attenuates hepatic damage and fibrosis in liver ischemia-reperfusion injury

Y Liu, T Lu, C Zhang, J Xu, Z Xue, RW Busuttil, N Xu… - Journal of …, 2019 - Elsevier
Background & Aims Hepatic ischemia-reperfusion injury (IRI) is a major complication of
hemorrhagic shock, liver resection and transplantation. YAP, a key downstream effector of …

[PDF][PDF] Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients

C Benítez, MC Londoño, R Miquel, TM Manzia… - …, 2013 - Wiley Online Library
Lifelong immunosuppression increases morbidity and mortality in liver transplantation.
Discontinuation of immunosuppressive drugs could lessen this burden, but the safety …

Health status of children alive 10 years after pediatric liver transplantation performed in the US and Canada: report of the studies of pediatric liver transplantation …

VL Ng, EM Alonso, JC Bucuvalas, G Cohen… - The Journal of …, 2012 - Elsevier
OBJECTIVES: To determine clinical and health-related quality of life outcomes, and to derive
an “ideal” composite profile of children alive 10 years after pediatric liver transplantation (LT) …

Efficacy and safety of immunosuppression withdrawal in pediatric liver transplant recipients: moving toward personalized management

S Feng, JC Bucuvalas, GV Mazariegos, JC Magee… - …, 2021 - Wiley Online Library
Background and Aims Tolerance is transplantation's holy grail, as it denotes allograft health
without immunosuppression and its toxicities. Our aim was to determine, among stable long …

Evidence of chronic allograft injury in liver biopsies from long-term pediatric recipients of liver transplants

S Feng, JC Bucuvalas, AJ Demetris, BE Burrell… - Gastroenterology, 2018 - Elsevier
Background & Aims A substantial proportion of pediatric liver transplant recipients develop
subclinical chronic allograft injury. We studied whether there are distinct patterns of injury …

[HTML][HTML] Pediatric liver transplantation

M Spada, S Riva, G Maggiore, D Cintorino… - World journal of …, 2009 - ncbi.nlm.nih.gov
In previous decades, pediatric liver transplantation has become a state-of-the-art operation
with excellent success and limited mortality. Graft and patient survival have continued to …

Outcomes of 5-year survivors of pediatric liver transplantation: report on 461 children from a North American multicenter registry

VL Ng, A Fecteau, R Shepherd, J Magee… - …, 2008 - publications.aap.org
OBJECTIVES. Although liver transplantation has been the standard of care therapy for life-
threatening liver diseases for> 20 years, data on the long-term impact of liver transplantation …