Fragment-based drug discovery (FBDD) has emerged in the past decade as a powerful tool
for discovering drug leads. The approach first identifies starting points: very small molecules …

Nuclear magnetic resonance, surface plasmon resonance and fluorescence spectroscopy
(particularly fluorescence anisotropy and fluorescence lifetime) are techniques often applied …

The efficacy of β-lactam antibiotics is threatened by the emergence and global spread of
metallo-β-lactamase (MBL) mediated resistance, specifically New Delhi metallo-β-lactamase …

A novel fragment-based drug discovery approach is reported which irreversibly tethers drug-
like fragments to catalytic cysteines. We attached an electrophile to 100 fragments without …

Studies in Natural Products Chemistry, Volume 79 covers the synthesis, testing and
recording of the medicinal properties of natural products, providing cutting-edge accounts of …

A novel strategy for the design of a fluorinated fragment library that takes into account the
local environment of fluorine is described. The procedure, based on a fluorine fingerprints …

Ligands that have an affinity for protein targets can be screened very effectively by exploiting
favorable properties of long‐lived states (LLS) in NMR spectroscopy. In this work, we …

Analysis of the results from the human proteome project suggests> 30% of proteins are
membrane bound. 1 Membrane proteins (MPs) are in the core group responsible for signal …

Fragment-based approaches have now become firmly established in the drug discovery
armoury. After notable early successes against protein kinases, the versatility and power of …

The emergence of metallo-β-lactamases (MBLs) capable of hydrolysing a broad spectrum of
β-lactam antibiotics is particularly concerning for the future treatment of bacterial infections …