New approaches to population stratification in genome-wide association studies

AL Price, NA Zaitlen, D Reich, N Patterson - Nature reviews genetics, 2010 - nature.com
Genome-wide association (GWA) studies are an effective approach for identifying genetic
variants associated with disease risk. GWA studies can be confounded by population …

Variance component model to account for sample structure in genome-wide association studies

HM Kang, JH Sul, SK Service, NA Zaitlen, S Kong… - Nature …, 2010 - nature.com
Although genome-wide association studies (GWASs) have identified numerous loci
associated with complex traits, imprecise modeling of the genetic relatedness within study …

Population structure and cryptic relatedness in genetic association studies

W Astle, DJ Balding - 2009 - projecteuclid.org
We review the problem of confounding in genetic association studies, which arises
principally because of population structure and cryptic relatedness. Many treatments of the …

Estimating FST and kinship for arbitrary population structures

A Ochoa, JD Storey - PLoS genetics, 2021 - journals.plos.org
F ST and kinship are key parameters often estimated in modern population genetics studies
in order to quantitatively characterize structure and relatedness. Kinship matrices have also …

ROADTRIPS: case-control association testing with partially or completely unknown population and pedigree structure

T Thornton, MS McPeek - The American Journal of Human Genetics, 2010 - cell.com
Genome-wide association studies are routinely conducted to identify genetic variants that
influence complex disorders. It is well known that failure to properly account for population or …

The identification of 14 new genes for meat quality traits in chicken using a genome-wide association study

Y Sun, G Zhao, R Liu, M Zheng, Y Hu, D Wu, L Zhang… - BMC genomics, 2013 - Springer
Background Meat quality is an important economic trait in chickens. To identify loci and
genes associated with meat quality traits, we conducted a genome-wide association study …

A comparison of association methods correcting for population stratification in case–control studies

C Wu, A DeWan, J Hoh, Z Wang - Annals of human genetics, 2011 - Wiley Online Library
Population stratification is an important issue in case–control studies of disease‐marker
association. Failure to properly account for population structure can lead to spurious …

Exploring genetic susceptibility to cancer in diverse populations

CA Haiman, DO Stram - Current opinion in genetics & development, 2010 - Elsevier
Incidence rates for many cancers differ markedly by race/ethnicity and furthering our
understanding of the genetic and environmental causes of such disparities is a scientific and …

Genome‐wide association study of shank length and diameter at different developmental stages in chicken F2 resource population

H Emrani, AA Masoudi, R Vaez Torshizi… - Animal …, 2020 - Wiley Online Library
In order to find SNPs and genes affecting shank traits, we performed a GWAS in a chicken
F2 population of eight half‐sib families from five hatches derived from reciprocal crosses …

Identification of new loci for body weight traits in F2 chicken population using genome-wide association study

H Emrani, RV Torshizi, AA Masoudi, A Ehsani - Livestock Science, 2017 - Elsevier
Understanding the genetic control of growth traits is one of the most important breeding
goals in poultry industry. In order to find genes and genomic regions affecting growth traits …