In recent decades, traditional eating habits have been replaced by a more globalized diet,
rich in saturated fatty acids and simple sugars. Extensive evidence shows that these dietary …

In both humans and animal models, consumption of a high-saturated-fat diet has been
linked to vascular dysfunction and cognitive impairments. Laboratory animals provide …

Early life Western diet (WD) consumption leads to impaired memory function, particularly for
processes mediated by the hippocampus. However, the precise critical developmental …

Menopause transition can be interpreted as a vulnerable state characterized by estrogen
deficiency with detrimental systemic effects as the low-grade chronic inflammation that …

Obesity, the cessation of ovarian steroids with menopause, and age are risk factors for mood
disorders, dementia, and Alzheimer's disease (AD). However, immediate hormone therapy …

Old male rhesus macaques often show cognitive impairment, and also have attenuated
circulating levels of testosterone and dehydroepiandrosterone sulfate (DHEAS). However, it …

The postmenopausal decrease in circulating estradiol (E2) levels has been shown to
contribute to several adverse physiological and psychiatric effects. To elucidate the …

In the brain, apolipoprotein E (apoE) plays an important role in lipid transport and response
to environmental and age-related challenges, including neuronal repair following injury …

Rhesus macaques develop amyloid-β (Aβ) plaques during old age, but it is unclear how
extensively they express other pathological hallmarks of dementia. Here we used …

Estrogens rapidly decline at the onset of menopause, putting women at higher risk of
osteoporosis, obesity, and neurodegenerative diseases, including Alzheimer's disease (AD) …