Understanding of the immediate mechanisms of Mn-induced neurotoxicity is rapidly
evolving. We seek to provide a summary of recent findings in the field, with an emphasis to …

Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a
cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant …

Manganese (Mn) is an essential trace element that is naturally found in the environment and
is necessary as a cofactor for many enzymes and is important in several physiological …

Studies have reported associations between environmental manganese (Mn) exposure and
impaired cognition, attention, impulse control, and fine motor function in children. Our recent …

Alpha-synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies and
multiple system atrophy, are characterized by aberrant accumulation of alpha-synuclein and …

Inherited autosomal recessive mutations of the manganese (Mn) transporter gene
SLC39A14 in humans, results in elevated blood and brain Mn concentrations and childhood …

Background Occupational studies have shown an association between elevated Mn
exposure and depressive symptoms. Blood Mn (BMn) naturally rises during pregnancy due …

Changes in trace element concentrations are being wildly considered when it comes to
neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. This …

Although noteworthy progress has been made in developing alternatives to animal testing,
nonhuman primates still play a critical role in advancing biomedical research and will likely …