Increased efforts in antimalarial drug discovery are urgently needed. The goal must be to
develop safe and affordable new drugs to counter the spread of malaria parasites that are …

Artemisinin-based combination treatments (ACTs) are now generally accepted as the best
treatments for uncomplicated falciparum malaria. They are rapidly and reliably effective …

Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in
malaria mortality and morbidity. Recent laboratory and clinical studies have associated …

Background Efficient allocation of resources to intervene against malaria requires a detailed
understanding of the contemporary spatial distribution of malaria risk. It is exactly 40 y since …

Malaria, caused mostly by Plasmodium falciparum and P. vivax, remains one of the most
important infectious diseases in the world. Antimalarial drug toxicity is one side of the risk …

BACKGROUND: Addition of artemisinin derivatives to existing drug regimens for malaria
could reduce treatment failure and transmission potential. We assessed the evidence for this …

Metabolic processes utilize a variety of differing and contrasting biochemical routes to
enable synthesis of degradation and activation or deactivation of substances; in addition …

Rolling back malaria is possible. Tools are available but they are not used. Several
countries deploy, as their national malaria control treatment policy, drugs that are no longer …

Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

Piperaquine is a bisquinoline antimalarial drug that was first synthesised in the 1960s, and
used extensively in China and Indochina as prophylaxis and treatment during the next 20 …