Vitamin K–sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity

P Mladěnka, K Macáková, L Kujovská Krčmová… - Nutrition …, 2022 - academic.oup.com
Vitamin K is traditionally connected with blood coagulation, since it is needed for the
posttranslational modification of 7 proteins involved in this cascade. However, it is also …

Cartilage calcification in osteoarthritis: mechanisms and clinical relevance

I Bernabei, A So, N Busso, S Nasi - Nature Reviews Rheumatology, 2023 - nature.com
Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be
observed both at the cartilage surface and in its deeper layers. The formation of calcium …

Sinomenine inhibits the progression of rheumatoid arthritis by regulating the secretion of inflammatory cytokines and monocyte/macrophage subsets

W Liu, Y Zhang, W Zhu, C Ma, J Ruan, H Long… - Frontiers in …, 2018 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory arthropathy associated with
articular damage and attendant comorbidities. Even although RA treatment has advanced …

Vitamin K as a diet supplement with impact in human health: current evidence in age-related diseases

DC Simes, CSB Viegas, N Araújo, C Marreiros - Nutrients, 2020 - mdpi.com
Vitamin K health benefits have been recently widely shown to extend beyond blood
homeostasis and implicated in chronic low-grade inflammatory diseases such as …

Vitamin K‑dependent proteins involved in bone and cardiovascular health

L Wen, J Chen, L Duan, S Li - Molecular medicine …, 2018 - spandidos-publications.com
In postmenopausal women and elderly men, bone density decreases with age and vascular
calcification is aggravated. This condition is closely associated with vitamin K2 deficiency. A …

Chronic kidney disease circulating calciprotein particles and extracellular vesicles promote vascular calcification: a role for GRP (Gla-Rich Protein)

CSB Viegas, L Santos, AL Macedo… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Inhibition of mineral crystal formation is a crucial step in ectopic calcification.
Serum calciprotein particles (CPPs) have been linked to chronic kidney disease (CKD) …

Vitamin K as a powerful micronutrient in aging and age-related diseases: pros and cons from clinical studies

DC Simes, CSB Viegas, N Araújo… - International journal of …, 2019 - mdpi.com
Vitamin K is a multifunctional micronutrient implicated in age-related diseases such as
cardiovascular diseases, osteoarthritis and osteoporosis. Although vitamin K-dependent …

[HTML][HTML] The interplay between mineral metabolism, vascular calcification and inflammation in Chronic Kidney Disease (CKD): challenging old concepts with new facts

C Viegas, N Araújo, C Marreiros, D Simes - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
Chronic kidney disease (CKD) is one of the most powerful predictors of premature
cardiovascular disease (CVD), with heightened susceptibility to vascular intimal and medial …

Vitamin K effects in human health: new insights beyond bone and cardiovascular health

M Fusaro, M Gallieni, C Porta, TL Nickolas… - Journal of …, 2020 - Springer
Vitamin K is a cofactor for the function of the enzyme γ-glutamyl carboxylase, necessary for
the activation of multiple vitamin K dependent-proteins. Vitamin K dependent-proteins …

The biological responses of vitamin K2: A comprehensive review

Q Yan, T Zhang, C O'Connor, JW Barlow… - Food Science & …, 2023 - Wiley Online Library
Abstract Vitamin K1 (VitK1) and Vitamin K2 (VitK2), two important naturally occurring
micronutrients in the VitK family, found, respectively, in green leafy plants and algae (VitK1) …