Phosphoinositides: tiny lipids with giant impact on cell regulation
T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
Mammalian phospholipase C
Phospholipase C (PLC) converts phosphatidylinositol 4, 5-bisphosphate (PIP2) to inositol 1,
4, 5-trisphosphate (IP3) and diacylglycerol (DAG). DAG and IP3 each control diverse cellular …
4, 5-trisphosphate (IP3) and diacylglycerol (DAG). DAG and IP3 each control diverse cellular …
Multiple roles of phosphoinositide-specific phospholipase C isozymes
PG Suh, JI Park, L Manzoli, L Cocco, JC Peak… - BMB …, 2008 - koreascience.kr
Phosphoinositide-specific phospholipase C is an effector molecule in the signal transduction
process. It generates two second messengers, inositol-1, 4, 5-trisphosphate and …
process. It generates two second messengers, inositol-1, 4, 5-trisphosphate and …
The phospholipase C isozymes and their regulation
A Gresset, J Sondek, TK Harden - Phosphoinositides I: Enzymes of …, 2012 - Springer
The physiological effects of many extracellular neurotransmitters, hormones, growth factors,
and other stimuli are mediated by receptor-promoted activation of phospholipase C (PLC) …
and other stimuli are mediated by receptor-promoted activation of phospholipase C (PLC) …
Phosphoinositide-specific phospholipase C in health and disease
L Cocco, MY Follo, L Manzoli, PG Suh - Journal of lipid research, 2015 - ASBMB
Phospholipases are widely occurring and can be found in several different organisms,
including bacteria, yeast, plants, animals, and viruses. Phospholipase C (PLC) is a class of …
including bacteria, yeast, plants, animals, and viruses. Phospholipase C (PLC) is a class of …
Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance
K Fukami, S Inanobe, K Kanemaru… - Progress in lipid research, 2010 - Elsevier
Spatial and temporal activation of phosphoinositide turnover enables eukaryotic cells to
perform various functions such as cell proliferation/differentiation, fertilization, neuronal …
perform various functions such as cell proliferation/differentiation, fertilization, neuronal …
Phospholipase c
CA Bill, CM Vines - Calcium signaling, 2019 - Springer
Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen
different family members have been cloned. These family members have unique structures …
different family members have been cloned. These family members have unique structures …
Phospholipase C families: Common themes and versatility in physiology and pathology
M Katan, S Cockcroft - Progress in lipid research, 2020 - Elsevier
Abstract Phosphoinositide-specific phospholipase Cs (PLCs) are expressed in all
mammalian cells and play critical roles in signal transduction. To obtain a comprehensive …
mammalian cells and play critical roles in signal transduction. To obtain a comprehensive …
Oocyte activation deficiency and assisted oocyte activation: mechanisms, obstacles and prospects for clinical application
BACKGROUND Oocyte activation deficiency (OAD) is attributed to the majority of cases
underlying failure of ICSI cycles, the standard treatment for male factor infertility. Oocyte …
underlying failure of ICSI cycles, the standard treatment for male factor infertility. Oocyte …
Epac-mediated activation of phospholipase Cɛ plays a critical role in β-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes
EA Oestreich, H Wang, S Malik… - Journal of Biological …, 2007 - ASBMB
Recently we demonstrated that PLCɛ plays an important role in β-adrenergic receptor (βAR)
stimulation of Ca 2+-induced Ca 2+ release (CICR) in cardiac myocytes. Here we have …
stimulation of Ca 2+-induced Ca 2+ release (CICR) in cardiac myocytes. Here we have …