The adenosine receptors (ARs) in the nervous system act as a kind of “go-between” to regulate the release of neurotransmitters (this includes all known neurotransmitters) and the …
Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the respective nucleosides. Within the past decade, ectonucleotidases belonging to several …
HK Eltzschig, D Köhler, T Eckle, T Kong… - Blood, The Journal …, 2009 - ashpublications.org
Hypoxia is common to several inflammatory diseases, where multiple cell types release adenine-nucleotides (particularly adenosine triphosphate/adenosine diphosphate) …
Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most potent compound was K6H2 [TiW11CoO40], exhibiting Ki values of 0.140 μM (NTPDase1) …
AJ Marcus, MJ Broekman… - … in thrombosis and …, 2005 - thieme-connect.com
Blood platelets maintain vascular integrity and promote primary and secondary hemostasis following interruption of vessel continuity. Biochemical or physical damage to coronary …
M al‐Rashida, J Iqbal - Medicinal Research Reviews, 2014 - Wiley Online Library
The modulatory role of extracellular nucleotides and adenosine in relevance to purinergic cell signaling mechanisms has long been known and is an object of much research …
T Kaur, B Weadick, TA Mace, K Desai, H Odom… - Pharmacology & …, 2022 - Elsevier
Adenosine compartmentalization has a profound impact on immune cell function by regulating adenosine localization and, therefore, extracellular signaling capabilities, which …
Nucleotide signaling is currently an area of intense investigation. Extracellular adenosine triphosphate (ATP) liberated during hypoxia or inflammation can either signal directly to …
SL Chi, SV Pizzo - Annals of medicine, 2006 - Taylor & Francis
The mitochondrial F1Fo adenosine triphosphate (ATP) synthase is one of the most thoroughly studied enzyme complexes known. Yet, a number of new observations …