Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …

The adenosine receptors (ARs) in the nervous system act as a kind of “go-between” to
regulate the release of neurotransmitters (this includes all known neurotransmitters) and the …

Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the
respective nucleosides. Within the past decade, ectonucleotidases belonging to several …

Hypoxia is common to several inflammatory diseases, where multiple cell types release
adenine-nucleotides (particularly adenosine triphosphate/adenosine diphosphate) …

Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most
potent compound was K6H2 [TiW11CoO40], exhibiting Ki values of 0.140 μM (NTPDase1) …

Blood platelets maintain vascular integrity and promote primary and secondary hemostasis
following interruption of vessel continuity. Biochemical or physical damage to coronary …

The modulatory role of extracellular nucleotides and adenosine in relevance to purinergic
cell signaling mechanisms has long been known and is an object of much research …

Adenosine compartmentalization has a profound impact on immune cell function by
regulating adenosine localization and, therefore, extracellular signaling capabilities, which …

Nucleotide signaling is currently an area of intense investigation. Extracellular adenosine
triphosphate (ATP) liberated during hypoxia or inflammation can either signal directly to …

The mitochondrial F1Fo adenosine triphosphate (ATP) synthase is one of the most
thoroughly studied enzyme complexes known. Yet, a number of new observations …