Clinical characterization of Lassa fever: A systematic review of clinical reports and research to inform clinical trial design

L Merson, J Bourner, S Jalloh, A Erber… - PLOS Neglected …, 2021 - journals.plos.org
Background Research is urgently needed to reduce the morbidity and mortality of Lassa
fever (LF), including clinical trials to test new therapies and to verify the efficacy and safety of …

Hemorrhagic fever-causing arenaviruses: lethal pathogens and potent immune suppressors

ME Brisse, H Ly - Frontiers in immunology, 2019 - frontiersin.org
Hemorrhagic fevers (HF) resulting from pathogenic arenaviral infections have traditionally
been neglected as tropical diseases primarily affecting African and South American regions …

Predicting the evolution of the Lassa virus endemic area and population at risk over the next decades

R Klitting, LE Kafetzopoulou, W Thiery, G Dudas… - Nature …, 2022 - nature.com
Lassa fever is a severe viral hemorrhagic fever caused by a zoonotic virus that repeatedly
spills over to humans from its rodent reservoirs. It is currently not known how climate and …

Delineating the mechanism of anti-Lassa virus GPC-A neutralizing antibodies

AS Enriquez, TK Buck, H Li, MJ Norris, A Moon-Walker… - Cell reports, 2022 - cell.com
Lassa virus (LASV) is the etiologic agent of Lassa Fever, a hemorrhagic disease that is
endemic to West Africa. During LASV infection, LASV glycoprotein (GP) engages with …

Pathogenicity and virulence mechanisms of Lassa virus and its animal modeling, diagnostic, prophylactic, and therapeutic developments

HL Murphy, H Ly - Virulence, 2021 - Taylor & Francis
Lassa fever (LF) is a deadly viral hemorrhagic disease that is endemic to West Africa. The
causative agent of LF is Lassa virus (LASV), which causes approximately 300,000 infections …

[HTML][HTML] Vaccine platforms for the prevention of Lassa fever

J Purushotham, T Lambe, SC Gilbert - Immunology Letters, 2019 - Elsevier
Lassa fever is an acute viral haemorrhagic illness caused by Lassa virus (LASV), which is
endemic throughout much of West Africa. The virus primarily circulates in the Mastomys …

Rapid protection induced by a single-shot Lassa vaccine in male cynomolgus monkeys

M Mateo, S Reynard, N Pietrosemoli… - Nature …, 2023 - nature.com
Abstract Lassa fever hits West African countries annually in the absence of licensed vaccine
to limit the burden of this viral hemorrhagic fever. We previously developed MeV-NP, a …

[HTML][HTML] Identification of the dietary supplement capsaicin as an inhibitor of Lassa virus entry

K Tang, X Zhang, Y Guo - Acta Pharmaceutica Sinica B, 2020 - Elsevier
The limited treatment options for the increasing occurrence of Lassa hemorrhagic fever in
West Africa poses an urgent need for the discovery and development of novel therapeutics …

Systematic review and meta-analysis of the epidemiology of Lassa virus in humans, rodents and other mammals in sub-Saharan Africa

S Kenmoe, S Tchatchouang… - PLoS neglected …, 2020 - journals.plos.org
Accurate data on the Lassa virus (LASV) human case fatality rate (CFR) and the prevalence
of LASV in humans, rodents and other mammals are needed for better planning of actions …

Circulation of Lassa virus across the endemic Edo-Ondo axis, Nigeria, with cross-species transmission between multimammate mice

AS Adesina, A Oyeyiola, A Obadare… - Emerging microbes & …, 2023 - Taylor & Francis
We phylogenetically compared sequences of the zoonotic Lassa virus (LASV) obtained from
Mastomys rodents in seven localities across the highly endemic Edo and Ondo States within …