Coumarin: A natural, privileged and versatile scaffold for bioactive compounds

A Stefanachi, F Leonetti, L Pisani, M Catto, A Carotti - Molecules, 2018 - mdpi.com
Many naturally occurring substances, traditionally used in popular medicines around the
world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal …

Recent advances in the synthesis of coumarin derivatives via Knoevenagel condensation: A review

RH Vekariya, HD Patel - Synthetic Communications, 2014 - Taylor & Francis
The synthesis of coumarins through Knoevenagel condensation is one of the most important
processes in synthetic organic chemistry and medicinal chemistry. Compounds including a …

Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts

G Melagraki, A Afantitis, O Igglessi-Markopoulou… - European journal of …, 2009 - Elsevier
In the present work a series of novel coumarin-3-carboxamides and their hybrids with the
alpha-lipoic acid were designed, synthesized and tested as potent antioxidant and anti …

Coumarins as cholinesterase inhibitors: A review

LG de Souza, MN Rennó, JD Figueroa-Villar - Chemico-biological …, 2016 - Elsevier
The first report in literature of the isolation of coumarin was in the year 1820. After this report,
other papers were published demonstrating the isolation and synthesis of coumarin and …

Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents

F Belluti, G Fontana, L Dal Bo, N Carenini… - Bioorganic & medicinal …, 2010 - Elsevier
The naturally occurring coumarins and resveratrol, attract great attention due to their wide
range of biological properties, including anticancer, antileukemic, antibacterial and anti …

Room temperature one-pot green synthesis of coumarin-3-carboxylic acids in water: a practical method for the large-scale synthesis

G Brahmachari - ACS Sustainable Chemistry & Engineering, 2015 - ACS Publications
A simple, facile, and convenient practical method for the room temperature one-pot
synthesis of a series of potentially biologically active coumarin-3-carboxylic acids has been …

Novel 3-alkanoyl/aroyl/heteroaroyl-2H-chromene-2-thiones: Synthesis and evaluation of their antioxidant activities

OM Singh, NS Devi, DS Thokchom… - European journal of …, 2010 - Elsevier
A facile, convenient and high yielding synthesis of a combinatorial library of 3-alkanoyl/aroyl/
heteroaroyl-2H-chromene-2-thiones has been developed by the condensation of easily …

Efficient Synthesis of Spiro[chromeno[2,3-d]pyrimidine-5,3′-indoline]-tetraones by a One-Pot and Three-Component Reaction

K Jadidi, R Ghahremanzadeh… - Journal of Combinatorial …, 2009 - ACS Publications
An efficient one-pot synthesis of novel 8, 9-dihydrospiro [chromeno [2, 3-d] pyrimidine-5, 3′-
indoline]-2, 2′, 4, 6 (1 H, 3 H, 7 H)-tetraone derivatives by a three-component condensation …

[PDF][PDF] Pharmacologically potentials of different substituted coumarin derivatives

M Asif - Chem. Int, 2015 - academia.edu
Coumarins are well recognized naturally occurring compounds which isolated and present
in large number of compounds in the plant kingdom. Mostly occur in higher plants, richest …

3-[Benzimidazo-and 3-[benzothiadiazoleimidazo-(1, 2-c) quinazolin-5-yl]-2H-chromene-2-ones as potent antimicrobial agents

BS Kuarm, YT Reddy, JV Madhav, PA Crooks… - Bioorganic & medicinal …, 2011 - Elsevier
A series of 3-[benzimidazo (1, 2-c) quinazolin-5-yl]-2H-chromene-2-one (6a–6f) and 3-
[benzothiadiazole-imidazo (1, 2-c) quinazolin-5-yl]-2H-chromene-2-one derivatives (7a–7f) …