Ca2+ is an important second messenger participating in many cellular activities; when
physicochemical insults deregulate its delicate homeostasis, it acts as an intrinsic stressor …

Caspase-mediated apoptosis is a major hindrance to tumour growth and metastasis.
Accordingly, defects in signalling pathways leading to the activation of caspases are …

Diabetic nephropathy is the leading cause of end‐stage renal disease in the Western world.
Poor glycemic control contributes to the development of diabetic nephropathy, but the …

Ubiquitous calpains (μ-and m-calpain) have been repeatedly implicated in apoptosis, but
the underlying mechanism (s) remain (s) to be elucidated. We examined ionomycin-induced …

Cross-talk between calpain and caspase proteolytic systems has complicated efforts to
determine their distinct roles in apoptotic cell death. This study examined the effect of …

Ubiquitously expressed micro-and millicalpain, which both require the calpain small 1
(CAPNS1) regulatory subunit for function, play important roles in numerous biological and …

To investigate a potential relationship between calpain and mitochondrial damage in spinal
cord injury (SCI), a 40 gram‐centimeter force (g‐cm) injury was induced in rats by a weight …

Oral squamous cell carcinoma (OSCC) is the most frequent oral malignancy, with a high
death rate and an inadequate response to conventional chemotherapeutic drugs. Medical …

Caspases are a family of cysteine proteases that predominantly cleave their substrates after
aspartic acid residues. Much of what we know of caspases emerged from investigation a …

Previous studies have shown that microcystin-LR (MLR), a specific hepatotoxin, induces
onset of mitochondrial permeability transition (MPT) and apoptosis in cultured rat …