Protein‐protein interactions as a target for drugs in proteomics

AI Archakov, VM Govorun, AV Dubanov… - …, 2003 - Wiley Online Library
Protein‐protein interactions play a central role in numerous processes in the cell and are
one of the main fields of functional proteomics. This review highlights the methods of …

The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors

L Silvestrini, N Belhaj, L Comez, Y Gerelli, A Lauria… - Scientific Reports, 2021 - nature.com
The maturation of coronavirus SARS-CoV-2, which is the etiological agent at the origin of the
COVID-19 pandemic, requires a main protease Mpro to cleave the virus-encoded …

The importance of protein-protein interactions on the pH-induced conformational changes of bovine serum albumin: a small-angle X-ray scattering study

LRS Barbosa, MG Ortore, F Spinozzi, P Mariani… - Biophysical journal, 2010 - cell.com
The combined effects of concentration and pH on the conformational states of bovine serum
albumin (BSA) are investigated by small-angle x-ray scattering. Serum albumins, at …

[PDF][PDF] GENFIT: software for the analysis of small-angle X-ray and neutron scattering data of macromolecules in solution

F Spinozzi, C Ferrero, MG Ortore… - Journal of applied …, 2014 - journals.iucr.org
Many research topics in the fields of condensed matter and the life sciences are based on
small-angle X-ray and neutron scattering techniques. With the current rapid progress in …

Combining structure and dynamics: non-denaturing high-pressure effect on lysozyme in solution

MG Ortore, F Spinozzi, P Mariani… - Journal of The …, 2009 - royalsocietypublishing.org
Small-angle X-ray scattering (SAXS) and elastic and quasi-elastic neutron scattering
techniques were used to investigate the high-pressure-induced changes on interactions, the …

Atomically detailed simulations of concentrated protein solutions: the effects of salt, pH, point mutations, and protein concentration in simulations of 1000-molecule …

SR McGuffee, AH Elcock - Journal of the American Chemical …, 2006 - ACS Publications
An ability to accurately simulate the dynamic behavior of concentrated macromolecular
solutions would be of considerable utility in studies of a wide range of biological systems …

Unveiling protein-protein interaction potential through Monte Carlo simulation combined with small-angle X-ray scattering

FT Tanouye, JR Alves, F Spinozzi, R Itri - International Journal of Biological …, 2023 - Elsevier
Protein interactions are investigated under different conditions of lysozyme concentration,
temperature and ionic strength by means of in-solution small angle X-Ray scattering (SAXS) …

Protein amyloidogenesis investigated by small angle scattering

C Ricci, F Spinozzi, P Mariani… - Current pharmaceutical …, 2016 - ingentaconnect.com
In the last decades, the study of the mechanisms inducing amyloid fibril formation has
involved several experimental and theoretical biophysical approaches. Many efforts have …

Preferential hydration of lysozyme in water/glycerol mixtures: A small-angle neutron scattering study

R Sinibaldi, MG Ortore, F Spinozzi… - The Journal of …, 2007 - pubs.aip.org
In solution small-angle neutron scattering has been used to study the solvation properties of
lysozyme dissolved in water/glycerol mixtures. To detect the characteristics of the protein …

Small angle X-ray scattering analysis of deoxyguanosine 5′-monophosphate self-assembing in solution: nucleation and growth of G-quadruplexes

P Mariani, F Spinozzi, F Federiconi… - The Journal of …, 2009 - ACS Publications
To solve details of the self-assembling process of guanosine in diluted aqueous solution
and to derive a thermodynamical model for quadruplex formation, the structural behavior of …