Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the
main neuroendocrine secretory product of the pineal gland. Although melatonin is best …

Angiogenesis depends on proangiogenic and anti-angiogenic molecules that regulate
endothelial cell proliferation and migration. Well-regulated angiogenesis plays a pivotal role …

Melatonin is mainly produced in the mammalian pineal gland during the dark phase. Its
secretion from the pineal gland has been classically associated with circadian and circanual …

Melatonin, a ubiquitous methoxyindole, is produced by and metabolized in the skin.
Melatonin affects skin functions and structures through actions mediated by cell-surface and …

Skin injuries and in particular, chronic wounds, are one of the major prevalent medical
problems, worldwide. Due to the pivotal role of angiogenesis in tissue regeneration …

Melatonin has been experimentally implicated in skin functions such as hair growth cycling,
fur pigmentation, and melanoma control, and melatonin receptors are expressed in several …

When exposed to hostile environments such as radiation, physical injuries, chemicals,
pollution, and microorganisms, the skin requires protective chemical molecules and …

Melatonin (N-acetyl-5-methoxytryptamine, MLT), the main hormone produced by the pineal
gland, not only regulates circadian rhythm, but also has antioxidant, anti-ageing and …

Pineal gland melatonin is the darkness hormone, while extra-pineal melatonin produced by
the gonads, gut, retina, and immune competent cells acts as a paracrine or autocrine …

Hydrogel-based drug delivery systems have emerged as a promising platform for chronic
tissue defects owing to their inherent ability to inhibit pathogenic infection and accelerate …