The mammalian cerebellum is located in the posterior cranial fossa and is critical for motor
coordination and non-motor functions including cognitive and emotional processes. The …

The relationship between wound healing and cancer has long been recognized. The
mechanisms that regulate wound healing have been shown to promote transformation and …

Progenitor heterogeneity and identities underlying tumor initiation and relapse in
medulloblastomas remain elusive. Utilizing single-cell transcriptomic analysis, we …

Hedgehog signaling is essential for tissue development and stemness, and its deregulation
has been observed in many tumors. Aberrant activation of Hedgehog signaling is the result …

Background Glioblastomas (GBM) comprise different subsets that exhibit marked
heterogeneity and plasticity, leading to a lack of success of genomic profiling in guiding the …

Medulloblastoma is one of the most common malignant pediatric brain tumors derived from
posterior fossa. The current treatment includes maximal safe surgical resection …

Forkhead box g1 (Foxg1) is a nuclear-cytosolic transcription factor essential for the forebrain
development and involved in neurodevelopmental and cancer pathologies. Despite the …

Hedgehog (Hh) inhibitors have emerged as valid tools in the treatment of a wide range of
cancers. Indeed, aberrant activation of the Hh pathway occurring either by ligand-dependent …

In medulloblastoma, abnormal expression of pluripotency factors such as LIN 28 and OCT 4
has been correlated with poor patient survival. The miR‐302/367 cluster has also been …

Medulloblastoma (MB) is the most common malignant primary intracranial neoplasm
diagnosed in childhood. Although numerous efforts have been made during the past few …