Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a
biologically uncontrolled process, whereas RCD involves tightly structured signaling …

Lysosomes and lysosomal hydrolases, including the cathepsins, have been shown to
change their properties with aging brain a long time ago, although their function was not …

Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases
that can degrade most cellular macromolecules. Lysosomal membrane permeabilization …

Mitochondrial outer membrane permeabilization (MOMP) constitutes one of the major
checkpoint (s) of apoptotic and necrotic cell death. Recently, the permeabilization of yet …

Lysosomal hydrolases participate in the digestion of endocytosed and autophagocytosed
material inside the lysosomal/autolysosomal compartment in acute cell death when released …

For many years apoptosis research has focused on caspases and their putative role as sole
executioners of programmed cell death. Accumulating information now suggests that …

Lysosomal membrane permeabilization (LMP) occurs in response to a large variety of cell
death stimuli causing release of cathepsins from the lysosomal lumen into the cytosol where …

During their lifetime, cells encounter many life or death situations that challenge their very
own existence. Their survival depends on the interplay within a complex yet precisely …

Bacteria-triggered sepsis is characterized by systemic, uncontrolled inflammation in affected
individuals. Controlling the excessive production of pro-inflammatory cytokines and …

Lysosomes, with their arsenal of degradative enzymes are increasingly becoming an area of
interest in the field of oncology. The changes induced in this compartment upon …