Bile acids as regulatory molecules and potential targets in metabolic diseases

A Xie, C Mai, YZ Zhu, XC Liu, Y Xie - Life Sciences, 2021 - Elsevier
Bile acids are important hydroxylated steroids that are synthesized in the liver from
cholesterol for intestinal absorption of lipids and other fatty-nutrient. They also display …

Ketogenic diet aggravates colitis, impairs intestinal barrier and alters gut microbiota and metabolism in DSS-induced mice

S Li, A Zhuge, K Wang, L Lv, X Bian, L Yang, J Xia… - Food & Function, 2021 - pubs.rsc.org
Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease with a high
incidence. Multiple factors including dietary composition contribute to its occurrence …

Integrated microbiome and metabolomic analysis reveal the repair mechanisms of ovalbumin on the intestine barrier of colitis mice

Q Yang, J Liu, T Li, S Lyu, X Liu, Z Du… - Journal of Agricultural …, 2023 - ACS Publications
The development and progression of colitis would detrimentally destroy the intestine barrier.
However, there remains a paucity of evidence on whether ovalbumin (OVA) can be used as …

Amelioration of methotrexate‐induced enteritis by melatonin in rats

N Jahovic, G Şener, H Çevik, Y Ersoy… - … biochemistry and its …, 2004 - Wiley Online Library
The anti‐tumour drug methotrexate (MTX) induces intestinal mucosa injury resulting in
malabsorption and diarrhoea. The purpose of this study was to investigate whether …

Potential antihypertensive mechanisms of the egg white-derived peptide QIGLF in spontaneously hypertensive rats revealed using untargeted serum metabolomics

Z Yu, W Xue, M Zhou, L Wang, S Wu… - Journal of Agricultural …, 2021 - ACS Publications
The angiotensin-converting enzyme (ACE) inhibitory peptide QIGLF derived from egg white
was shown to have significant in vivo antihypertensive effects in our previous study, but the …

Multi-omics analysis reveals the interaction of gut microbiome and host microRNAs in ulcerative colitis

L Ma, C Hou, H Yang, Q Chen, W Lyu, Z Wang… - Annals of …, 2023 - Taylor & Francis
Background Inflammatory bowel disease (IBD) is a chronic inflammation of the
gastrointestinal tract that co-occurs with gut microbiota dysbiosis; however, its etiology …

Integrating 16S RRNA gene sequencing and metabolomics to evaluate the association between gut microbiota and serum metabolites in patients with myositis

YB Luo, Y Liu, Q Li, H Duan, Z Luo… - Journal of applied …, 2022 - academic.oup.com
Aims Gut microbiota and metabolites have a profound impact on the maintenance of body
health. In this study, we assessed the association between gut microbiota and serum …

Protective Effect of Calculus Bovis Sativus on Dextran Sulphate Sodium‐Induced Ulcerative Colitis in Mice

X Li, Y Xu, C Zhang, L Deng, M Chang… - Evidence‐Based …, 2015 - Wiley Online Library
Calculus Bovis Sativus (CBS) is a commonly used traditional Chinese medicine, which has
been reported to exhibit antispasmodic, fever‐reducing, anti‐inflammatory, and gallbladder …

[HTML][HTML] Yiqi Jiemin decoction alleviates allergic rhinitis in a guinea pig model by suppressing inflammation, restoring Th1/Th2 balance, and improving cellular …

Z Yan, L Liu, J Yuan, L Jiao, M Zhou, J Liu… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
We investigated the mechanisms underlying the therapeutic effects of Yiqi Jiemin decoction
(YJD), a traditional Chinese medicine (TCM), in the ovalbumin (OVA)-induced allergic …

The identification of metabolites from gut microbiota in coronary heart disease via network pharmacology

HM Zhou, XY Yang, SJ Yue, WX Wang… - Artificial Cells …, 2024 - Taylor & Francis
Although the gut microbial metabolites exhibit potential effects on coronary heart disease
(CHD), the underlying mechanism remains unclear. In this study, the active gut microbial …