Deciphering the dynamic code: DNA recognition by transcription factors in the ever-changing genome
Transcription factors (TFs) intricately navigate the vast genomic landscape to locate and
bind specific DNA sequences for the regulation of gene expression programs. These …
bind specific DNA sequences for the regulation of gene expression programs. These …
The marionette mechanism of domain–domain communication in the antagonist, agonist, and coactivator responses of the estrogen receptor
The human estrogen receptor α (hER α) is involved in the regulation of growth,
development, and tissue homeostasis. Agonists that bind to the receptor's ligand-binding …
development, and tissue homeostasis. Agonists that bind to the receptor's ligand-binding …
Multi-scale gene regulation mechanism: Spatiotemporal transmission of genetic information
Y Xue, J Wang, Y He, P Patra, YQ Gao - Current Opinion in Structural …, 2022 - Elsevier
Gene expression is regulated by many factors, including transcription factors, chromatin
three-dimensional topology, modifications of DNA and histone proteins, and non-coding …
three-dimensional topology, modifications of DNA and histone proteins, and non-coding …
Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR
I Freda, C Exertier, A Barile… - Nucleic Acids …, 2023 - academic.oup.com
Specificity in protein–DNA recognition arises from the synergy of several factors that stem
from the structural and chemical signatures encoded within the targeted DNA molecule …
from the structural and chemical signatures encoded within the targeted DNA molecule …
Role of Shape Deformation of DNA-Binding Sites in Regulating the Efficiency and Specificity in Their Recognition by DNA-Binding Proteins
SK Mishra, A Bhattacherjee - JACS Au, 2024 - pmc.ncbi.nlm.nih.gov
Accurate transcription of genetic information is crucial, involving precise recognition of the
binding motifs by DNA-binding proteins. While some proteins rely on short-range …
binding motifs by DNA-binding proteins. While some proteins rely on short-range …
Zeta potential of Z-DNA: A new signature to study BZ transition in linear and branched DNA
Zeta potential is commonly referred as surface charge density and is a key factor in
modulating the structural and functional properties of nucleic acids. Although the negative …
modulating the structural and functional properties of nucleic acids. Although the negative …
Skipping events impose repeated binding attempts: profound kinetic implications of protein–DNA conformational changes
E Rogoulenko, Y Levy - Nucleic Acids Research, 2024 - academic.oup.com
The kinetics of protein–DNA recognition, along with its thermodynamic properties, including
affinity and specificity, play a central role in shaping biological function. Protein–DNA …
affinity and specificity, play a central role in shaping biological function. Protein–DNA …
Role of Shape Deformation of DNA-Binding Sites in Regulating the Efficiency and Specificity in Their Recognition by DNA-Binding Proteins
Accurate transcription of genetic information is crucial, involving precise recognition of the
binding motifs by DNA-binding proteins. While some proteins rely on short-range …
binding motifs by DNA-binding proteins. While some proteins rely on short-range …
[HTML][HTML] Pd (II)/1, 10-phenanthroline complexes bearing arene ligands: On the role of N-vs O-coordination to tune their cellular activity and binding ability towards DNA …
Three Pd (II)-based complexes of 1, 10-phenanthroline and N-or O-coordinating ligands
have been synthesised and tested with different relevant biosubstrates like double-stranded …
have been synthesised and tested with different relevant biosubstrates like double-stranded …
Molecular analysis of changes in DNA binding affinity and bending extent induced by the mutations on the aromatic amino residues in Cren7
Proteins from Crenarchaeal organisms exhibit remarkable thermal stability. The aromatic
amino acids in Cren7, a Crenarchaeal protein, regulate protein stability and further modulate …
amino acids in Cren7, a Crenarchaeal protein, regulate protein stability and further modulate …