Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation

MP Muller, T Jiang, C Sun, M Lihan, S Pant… - Chemical …, 2019 - ACS Publications
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

The plasma membrane as a mechanochemical transducer

AL Le Roux, X Quiroga, N Walani… - … of the Royal …, 2019 - royalsocietypublishing.org
Cells are constantly submitted to external mechanical stresses, which they must withstand
and respond to. By forming a physical boundary between cells and their environment that is …

When physics takes over: BAR proteins and membrane curvature

M Simunovic, GA Voth, A Callan-Jones… - Trends in cell …, 2015 - cell.com
Cell membranes become highly curved during membrane trafficking, cytokinesis, infection,
immune response, or cell motion. Bin/amphiphysin/Rvs (BAR) domain proteins with their …

The 2018 biomembrane curvature and remodeling roadmap

P Bassereau, R Jin, T Baumgart… - Journal of physics D …, 2018 - iopscience.iop.org
The importance of curvature as a structural feature of biological membranes has been
recognized for many years and has fascinated scientists from a wide range of different …

Compartmentalizing cell-free systems: toward creating life-like artificial cells and beyond

E Cho, Y Lu - ACS Synthetic Biology, 2020 - ACS Publications
Building an artificial cell is a research area that is rigorously studied in the field of synthetic
biology. It has brought about much attention with the aim of ultimately constructing a natural …

Membrane sculpting by curved DNA origami scaffolds

HG Franquelim, A Khmelinskaia, JP Sobczak… - Nature …, 2018 - nature.com
Membrane sculpting and transformation is essential for many cellular functions, thus being
largely regulated by self-assembling and self-organizing protein coats. Their functionality is …

[HTML][HTML] Non-Brownian diffusion in lipid membranes: Experiments and simulations

R Metzler, JH Jeon, AG Cherstvy - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
The dynamics of constituents and the surface response of cellular membranes—also in
connection to the binding of various particles and macromolecules to the membrane—are …

Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly

K Tsujita, R Satow, S Asada, Y Nakamura… - Nature …, 2021 - nature.com
Malignancy is associated with changes in cell mechanics that contribute to extensive cell
deformation required for metastatic dissemination. We hypothesized that the cell-intrinsic …

Curving cells inside and out: roles of BAR domain proteins in membrane shaping and its cellular implications

M Simunovic, E Evergren… - Annual review of cell …, 2019 - annualreviews.org
Many cellular processes rely on precise and timely deformation of the cell membrane. While
many proteins participate in membrane reshaping and scission, usually in highly specialized …

Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR

B Simonetti, CM Danson, KJ Heesom… - Journal of Cell Biology, 2017 - rupress.org
Endosomal recycling of transmembrane proteins requires sequence-dependent recognition
of motifs present within their intracellular cytosolic domains. In this study, we have …